Rexulti and Stroke - a phase IV clinical study of FDA data

Summary:

Stroke is reported as a side effect among people who take Rexulti (brexpiprazole), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Wellbutrin, and have Depression.

The phase IV clinical study analyzes which people have Stroke when taking Rexulti. It is created by eHealthMe based on reports of 13,206 people who have side effects when taking Rexulti from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,393 Rexulti users. Check the latest studies of Rexulti.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 2,458 drugs and 3,004 conditions by eHealthMe. Check the latest studies of Stroke.

On Sep, 18, 2025

13,206 people reported to have side effects when taking Rexulti.
Among them, 49 people (0.37%) have Stroke.

Among these 49 people:

How long have people been on Rexulti when they have Stroke? *

What is the gender of people who have Stroke when taking Rexulti? *

female: 71.74 %
male: 28.26 %

What is the age of people who have Stroke when taking Rexulti? *

What are other drugs people take besides Rexulti? *

What are other side effects people have besides Stroke? *

Akathisia (a movement disorder characterized by a feeling of inner restlessness): 4 people, 8.16%
Speech Impairment (Adult) (inability to speak (adult)): 4 people, 8.16%
Hypoaesthesia (reduced sense of touch or sensation): 3 people, 6.12%
Parkinson's Disease: 3 people, 6.12%
Facial Paralysis (loss of function of face muscle): 3 people, 6.12%
Gait Disturbance: 3 people, 6.12%
Vision Blurred: 3 people, 6.12%
Drowsiness: 3 people, 6.12%
Fall: 3 people, 6.12%
Fatigue (feeling of tiredness): 3 people, 6.12%

What are the existing conditions these people have? *

Depression: 11 people, 22.45%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 4 people, 8.16%
Parkinson's Disease: 2 people, 4.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 4.08%
Bipolar Disorder (mood disorder): 2 people, 4.08%
Stress And Anxiety: 2 people, 4.08%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 4.08%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 4.08%
Psychotic Disorder: 2 people, 4.08%
Cardiac Murmur (an heart sound in valve abnormality): 1 person, 2.04%

* Approximation only. Some reports may have incomplete information.

Do you take Rexulti and have Stroke?

- Check whether Stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rexulti:

Rexulti (13,393 reports)

Stroke treatments and more:

Stroke (334,630 reports)

How severe was Stroke and when was it recovered:

Stroke in Rexulti

Browse all side effects of Rexulti:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke:

Stroke (2,458 drugs)

Browse all the conditions that are associated with Stroke:

Stroke (3,004 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brexpiprazole (the active ingredients of Rexulti) and Rexulti (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.