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Ritalin and Bone marrow oedema - a phase IV clinical study of FDA data

Summary:

Bone marrow oedema is reported as a side effect among people who take Ritalin (methylphenidate hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Bone marrow oedema when taking Ritalin. It is created by eHealthMe based on reports of 26,179 people who have side effects when taking Ritalin from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Bone marrow oedema?

Bone marrow oedema (inflammation that causes much than the needed fluid in a bone) is found to be associated with 306 drugs and 298 conditions by eHealthMe. Check the latest studies of Bone marrow oedema.

On Jul, 13, 2026

26,179 people reported to have side effects when taking Ritalin.
Among them, 26 people (0.1%) have Bone marrow oedema.

Could Ritalin cause Bone marrow oedema?

Among these 26 people:

How long have people been on Ritalin when they have Bone marrow oedema? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Bone marrow oedema when taking Ritalin? *

  • female: 11.54 %
  • male: 88.46 %

What is the age of people who have Bone marrow oedema when taking Ritalin? *

  • 0-1: 0.0 %
  • 2-9: 4.17 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 25.0 %
  • 50-59: 33.33 %
  • 60+: 37.5 %

What are other drugs people take besides Ritalin? *

  1. Zometa: 24 people, 92.31%
  2. Oxycontin: 23 people, 88.46%
  3. Miacalcin: 23 people, 88.46%
  4. Folic Acid: 22 people, 84.62%
  5. Zoloft: 21 people, 80.77%
  6. Cephalexin: 17 people, 65.38%
  7. Ambien: 17 people, 65.38%
  8. Vioxx: 17 people, 65.38%
  9. Compazine: 17 people, 65.38%
  10. Zofran: 16 people, 61.54%

What are other side effects people have besides Bone marrow oedema? *

  1. Anaemia (lack of blood): 25 people, 96.15%
  2. Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 92.31%
  3. Osteoporosis (bones weak and more likely to break): 24 people, 92.31%
  4. Cellulitis (infection under the skin): 23 people, 88.46%
  5. Pain: 23 people, 88.46%
  6. Scar: 23 people, 88.46%
  7. High Blood Pressure: 23 people, 88.46%
  8. Broken Bone: 22 people, 84.62%
  9. Haematuria (presence of blood in urine): 22 people, 84.62%
  10. Pleural Effusion (water on the lungs): 21 people, 80.77%

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 7 people, 26.92%
  2. Inflammation: 5 people, 19.23%
  3. Renal Cell Carcinoma (a kidney cancer): 2 people, 7.69%
  4. Respiratory Tract Infection: 1 person, 3.85%
  5. Psychotic Disorder: 1 person, 3.85%
  6. Pneumonia: 1 person, 3.85%
  7. Oedema (fluid collection in tissue): 1 person, 3.85%
  8. Multiple Myeloma (cancer of the plasma cells): 1 person, 3.85%
  9. Metastases To Bone (cancer spreads to bone): 1 person, 3.85%
  10. Malignant Urinary Tract Neoplasm (cancer tumour of urinary tract organs): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Ritalin and have Bone marrow oedema?

- Check whether Bone marrow oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ritalin:

Bone marrow oedema treatments and more:

How severe was Bone marrow oedema and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone marrow oedema:

Browse all the conditions that are associated with Bone marrow oedema:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Ritalin) and Ritalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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