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Ritalin and Hepatic encephalopathy - a phase IV clinical study of FDA data

Summary:

Hepatic encephalopathy is reported as a side effect among people who take Ritalin (methylphenidate hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Cymbalta, and have Insomnia.

The phase IV clinical study analyzes which people have Hepatic encephalopathy when taking Ritalin. It is created by eHealthMe based on reports of 26,179 people who have side effects when taking Ritalin from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Hepatic encephalopathy?

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure) is found to be associated with 914 drugs and 1,259 conditions by eHealthMe. Check the latest studies of Hepatic encephalopathy.

On Jul, 12, 2026

26,179 people reported to have side effects when taking Ritalin.
Among them, 12 people (0.05%) have Hepatic encephalopathy.

Could Ritalin cause Hepatic encephalopathy?

Among these 12 people:

How long have people been on Ritalin when they have Hepatic encephalopathy? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hepatic encephalopathy when taking Ritalin? *

  • female: 41.67 %
  • male: 58.33 %

What is the age of people who have Hepatic encephalopathy when taking Ritalin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 12.5 %
  • 20-29: 0.0 %
  • 30-39: 12.5 %
  • 40-49: 12.5 %
  • 50-59: 12.5 %
  • 60+: 50.0 %

What are other drugs people take besides Ritalin? *

  1. Cymbalta: 7 people, 58.33%
  2. Albuterol: 5 people, 41.67%
  3. Alcohol: 5 people, 41.67%
  4. Ambien: 5 people, 41.67%
  5. Toradol: 5 people, 41.67%
  6. Naproxen: 2 people, 16.67%
  7. Zofran: 2 people, 16.67%
  8. Seroquel: 2 people, 16.67%
  9. Oxycodone: 2 people, 16.67%
  10. Haldol: 1 person, 8.33%

What are other side effects people have besides Hepatic encephalopathy? *

  1. Delirium (wild excitement): 8 people, 66.67%
  2. Hypotension (abnormally low blood pressure): 7 people, 58.33%
  3. Cellulitis (infection under the skin): 6 people, 50.00%
  4. Headache (pain in head): 6 people, 50.00%
  5. Fever: 6 people, 50.00%
  6. Abdominal Discomfort: 5 people, 41.67%
  7. Stress And Anxiety: 5 people, 41.67%
  8. Acute Kidney Failure: 5 people, 41.67%
  9. Alanine Aminotransferase Increased: 5 people, 41.67%
  10. Aspartate Aminotransferase Increased: 5 people, 41.67%

What are the existing conditions these people have? *

  1. Insomnia (sleeplessness): 6 people, 50.00%
  2. Pain: 2 people, 16.67%
  3. Nausea (feeling of having an urge to vomit): 2 people, 16.67%
  4. Infection: 2 people, 16.67%
  5. General Physical Health Deterioration (weak health status): 2 people, 16.67%
  6. Fever: 2 people, 16.67%
  7. Wheezing (a high-pitched whistling sound made while you breath): 1 person, 8.33%
  8. Vocal Cord Disorder: 1 person, 8.33%
  9. Hepatocellular Carcinoma (liver cancer): 1 person, 8.33%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ritalin and have Hepatic encephalopathy?

- Check whether Hepatic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ritalin:

Hepatic encephalopathy treatments and more:

How severe was Hepatic encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic encephalopathy:

Browse all the conditions that are associated with Hepatic encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Ritalin) and Ritalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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