Rybelsus and Pollakiuria - a phase IV clinical study of FDA data

Summary:

Pollakiuria is reported as a side effect among people who take Rybelsus (semaglutide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tivicay, and have Hiv infection.

The phase IV clinical study analyzes which people have Pollakiuria when taking Rybelsus. It is created by eHealthMe based on reports of 4,111 people who have side effects when taking Rybelsus from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Pollakiuria?

Pollakiuria (abnormally frequent passage of relatively small quantities or urine) is found to be associated with 1,743 drugs and 1,694 conditions by eHealthMe. Check the latest studies of Pollakiuria.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

4,111 people reported to have side effects when taking Rybelsus.
Among them, 24 people (0.58%) have Pollakiuria.

Among these 24 people:

How long have people been on Rybelsus when they have Pollakiuria? *

What is the gender of people who have Pollakiuria when taking Rybelsus? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Pollakiuria when taking Rybelsus? *

What are other drugs people take besides Rybelsus? *

What are other side effects people have besides Pollakiuria? *

Pain: 5 people, 20.83%
Stress And Anxiety: 5 people, 20.83%
Chronic Kidney Disease: 4 people, 16.67%
Weakness: 4 people, 16.67%
Emotional Distress: 4 people, 16.67%
Thirst: 4 people, 16.67%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 4 people, 16.67%
Blood Glucose Increased: 3 people, 12.50%
Fall: 3 people, 12.50%
Weight Increased: 3 people, 12.50%

What are the existing conditions these people have? *

Hiv Infection: 4 people, 16.67%
Type 2 Diabetes: 3 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.17%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 4.17%
Diabetes: 1 person, 4.17%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 4.17%
Cardiac Disorder: 1 person, 4.17%
Breast Cancer Metastatic: 1 person, 4.17%
Breast Cancer Female: 1 person, 4.17%
Blood Pressure Abnormal: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Rybelsus and have Pollakiuria?

- Check whether Pollakiuria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rybelsus:

Rybelsus (4,159 reports)

Pollakiuria treatments and more:

Pollakiuria (53,752 reports)

Browse all side effects of Rybelsus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pollakiuria:

Pollakiuria (1,743 drugs)

Browse all the conditions that are associated with Pollakiuria:

Pollakiuria (1,694 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Rybelsus) and Rybelsus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.