Rytary and Aggression - a phase IV clinical study of FDA data

Summary:

Aggression is reported as a side effect among people who take Rytary (carbidopa; levodopa), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Aggression when taking Rytary. It is created by eHealthMe based on reports of 17,236 people who have side effects when taking Rytary from the FDA, and is updated regularly.

What is Rytary?

Rytary has active ingredients of carbidopa; levodopa. eHealthMe is studying from 17,270 Rytary users. Check the latest studies of Rytary.

What is Aggression?

Aggression is found to be associated with 1,551 drugs and 1,963 conditions by eHealthMe. Check the latest studies of Aggression.

On Jul, 15, 2026

17,236 people reported to have side effects when taking Rytary.
Among them, 131 people (0.76%) have Aggression.

Among these 131 people:

* Approximation only. Some reports may have incomplete information.

Do you take Rytary and have Aggression?

- Check whether Aggression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rytary:

Rytary (17,270 reports)

Aggression treatments and more:

Aggression (65,312 reports)

How severe was Aggression and when was it recovered:

Aggression in Rytary

Expand to all the drugs that have ingredients of carbidopa; levodopa:

Aggression and drugs with ingredients of carbidopa; levodopa (773 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rytary:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aggression:

Aggression (1,551 drugs)

Browse all the conditions that are associated with Aggression:

Aggression (1,963 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Rytary) and Rytary (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.