Samsca and Peripheral coldness - a phase IV clinical study of FDA data

Summary:

Peripheral coldness is reported only by a few people who take Samsca.

The study analyzes which people take Samsca and have Peripheral coldness. It is created by eHealthMe based on reports of 8,134 people who have side effects while taking Samsca from the FDA, and is updated regularly.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

What is Peripheral coldness?

Peripheral coldness is found to be associated with 1,193 drugs and 1,141 conditions by eHealthMe. Check the latest studies of Peripheral coldness.

On Dec, 05, 2025

8,134 people reported to have side effects when taking Samsca.
Among them, 5 people (0.06%) have Peripheral coldness.

Among these 5 people:

How long have people been on Samsca when they have Peripheral coldness? *

What is the gender of people who have Peripheral coldness when taking Samsca? *

female: 60 %
male: 40 %

What is the age of people who have Peripheral coldness when taking Samsca? *

What are other drugs people take besides Samsca? *

What are other side effects people have besides Peripheral coldness? *

Cardiac Failure: 4 people, 80.00%
Acute Kidney Failure: 3 people, 60.00%
Weakness: 3 people, 60.00%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 3 people, 60.00%
Oedema Peripheral (superficial swelling): 2 people, 40.00%
General Physical Health Deterioration (weak health status): 2 people, 40.00%
Hyperkalemia (damage to or disease of the kidney): 2 people, 40.00%
Hypotension (abnormally low blood pressure): 2 people, 40.00%
Chest Pain: 2 people, 40.00%
Bradycardia (abnormally slow heart action): 2 people, 40.00%

What are the existing conditions these people have? *

Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 40.00%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 40.00%
High Blood Pressure: 2 people, 40.00%
Renal Artery Stenosis (narrowing of renal artery): 1 person, 20.00%
Blood Phosphorus Abnormal: 1 person, 20.00%
Cardiac Failure Congestive: 1 person, 20.00%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 1 person, 20.00%
Chronic Kidney Disease: 1 person, 20.00%
Chronic Renal Failure (kidney failure): 1 person, 20.00%
Depression: 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Samsca and have Peripheral coldness?

- Check whether Peripheral coldness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Samsca:

Samsca (8,139 reports)

Browse all side effects of Samsca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral coldness:

Peripheral coldness (1,193 drugs)

Browse all the conditions that are associated with Peripheral coldness:

Peripheral coldness (1,141 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tolvaptan (the active ingredients of Samsca) and Samsca (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.