Saphris and Acute kidney failure - a phase IV clinical study of FDA data

Summary:

Acute kidney failure is reported as a side effect among people who take Saphris (asenapine maleate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Nexium, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Acute kidney failure when taking Saphris. It is created by eHealthMe based on reports of 8,449 people who have side effects when taking Saphris from the FDA, and is updated regularly.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

What is Acute kidney failure?

Acute kidney failure is found to be associated with 2,831 drugs and 4,491 conditions by eHealthMe. Check the latest studies of Acute kidney failure.

On Jul, 06, 2026

8,449 people reported to have side effects when taking Saphris.
Among them, 45 people (0.53%) have Acute kidney failure.

Could Saphris cause Acute kidney failure?

Among these 45 people:

How long have people been on Saphris when they have Acute kidney failure? *

What is the gender of people who have Acute kidney failure when taking Saphris? *

female: 64.1 %
male: 35.9 %

What is the age of people who have Acute kidney failure when taking Saphris? *

What are other drugs people take besides Saphris? *

What are other side effects people have besides Acute kidney failure? *

Chronic Kidney Disease: 14 people, 31.11%
Hepatic Failure (liver failure): 5 people, 11.11%
Nephrogenic Anaemia (anaemia due to kidney disease): 5 people, 11.11%
Bradycardia (abnormally slow heart action): 4 people, 8.89%
Cardiac Arrest: 4 people, 8.89%
Dizziness: 4 people, 8.89%
Erythema Multiforme (a type of hypersensitivity reaction): 4 people, 8.89%
Fatigue (feeling of tiredness): 4 people, 8.89%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 4 people, 8.89%
Interstitial Nephritis (inflammation of the kidney): 4 people, 8.89%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 22.22%
High Blood Cholesterol: 10 people, 22.22%
Depression: 6 people, 13.33%
High Blood Pressure: 5 people, 11.11%
Stress And Anxiety: 5 people, 11.11%
Pain: 5 people, 11.11%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 8.89%
Diabetes: 4 people, 8.89%
Insomnia (sleeplessness): 3 people, 6.67%
Prostatomegaly (enlargement of the prostate): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Saphris and have Acute kidney failure?

- Check whether Acute kidney failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Saphris:

Saphris (8,688 reports)

Browse all side effects of Saphris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute kidney failure:

Acute kidney failure (2,831 drugs)

Browse all the conditions that are associated with Acute kidney failure:

Acute kidney failure (4,491 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on asenapine maleate (the active ingredients of Saphris) and Saphris (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.