Senna and Ankylosing spondylitis - a phase IV clinical study of FDA data

Summary:

Ankylosing spondylitis is reported as a side effect among people who take Senna (senna), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Ambien, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Ankylosing spondylitis when taking Senna. It is created by eHealthMe based on reports of 37,042 people who have side effects when taking Senna from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 742 drugs and 1,051 conditions by eHealthMe. Check the latest studies of Ankylosing spondylitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

37,042 people reported to have side effects when taking Senna.
Among them, 15 people (0.04%) have Ankylosing spondylitis.

Could Senna cause Ankylosing spondylitis?

Among these 15 people:

How long have people been on Senna when they have Ankylosing spondylitis? *

What is the gender of people who have Ankylosing spondylitis when taking Senna? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Ankylosing spondylitis when taking Senna? *

What are other drugs people take besides Senna? *

What are other side effects people have besides Ankylosing spondylitis? *

Stress And Anxiety: 11 people, 73.33%
Depression: 10 people, 66.67%
Intervertebral Disc Degeneration (spinal disc degeneration): 9 people, 60.00%
Haematochezia (passage of stools containing blood): 9 people, 60.00%
Osteonecrosis Of Jaw (death of bone of jaw): 8 people, 53.33%
Pain: 8 people, 53.33%
Myelitis Transverse (a neurological condition consisting of an inflammatory process of the spinal cord): 8 people, 53.33%
Pleural Fibrosis (formation of fibrous tissue in lung): 8 people, 53.33%
Joint Pain: 8 people, 53.33%
Post Laminectomy Syndrome: 8 people, 53.33%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 53.33%
Chest Pain: 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
Pain: 3 people, 20.00%
Headache (pain in head): 2 people, 13.33%
Insomnia (sleeplessness): 2 people, 13.33%
Endocarditis Bacterial (an inflammation of the inner layer of the heart by bacterial infection): 2 people, 13.33%
Nausea And Vomiting: 2 people, 13.33%
Pulmonary Congestion (congestion in the lungs): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Senna and have Ankylosing spondylitis?

- Check whether Ankylosing spondylitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Senna:

Senna (37,302 reports)

Browse all side effects of Senna:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (742 drugs)

Browse all the conditions that are associated with Ankylosing spondylitis:

Ankylosing spondylitis (1,051 conditions)

Related publications that referenced our studies

Hung YM, Cheng CC, Wann SR, Lin SL, "Ankylosing spondylitis associated with pulmonary arterial hypertension", Internal Medicine, 2016 Jan .
Hung YM, Cheng CC, Wann SR, Lin SL, "Ankylosing spondylitis associated with pulmonary arterial hypertension", Internal Medicine, 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on senna (the active ingredients of Senna) and Senna (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.