Seroquel and Osteolysis - a phase IV clinical study of FDA data

Summary:

Osteolysis is reported as a side effect among people who take Seroquel (quetiapine fumarate), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Ativan, and have Osteoporosis.

The phase IV clinical study analyzes which people have Osteolysis when taking Seroquel. It is created by eHealthMe based on reports of 113,615 people who have side effects when taking Seroquel from the FDA, and is updated regularly.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

What is Osteolysis?

Osteolysis (dissolution of bone) is found to be associated with 689 drugs and 407 conditions by eHealthMe. Check the latest studies of Osteolysis.



On Jul, 18, 2026

113,615 people reported to have side effects when taking Seroquel.
Among them, 33 people (0.03%) have Osteolysis.

Could Seroquel cause Osteolysis?

Among these 33 people:

How long have people been on Seroquel when they have Osteolysis? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Osteolysis when taking Seroquel? *

  • female: 43.75 %
  • male: 56.25 %

What is the age of people who have Osteolysis when taking Seroquel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 6.67 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 53.33 %
  • 50-59: 20.0 %
  • 60+: 20.0 %

What are other drugs people take besides Seroquel? *

  1. Zometa: 28 people, 84.85%
  2. Ativan: 28 people, 84.85%
  3. Zoloft: 21 people, 63.64%
  4. Aredia: 20 people, 60.61%
  5. Effexor: 20 people, 60.61%
  6. Coumadin: 19 people, 57.58%
  7. Aspirin: 18 people, 54.55%
  8. Remeron: 17 people, 51.52%
  9. Avandia: 17 people, 51.52%
  10. Elavil: 16 people, 48.48%

What are other side effects people have besides Osteolysis? *

  1. Pain: 30 people, 90.91%
  2. Stress And Anxiety: 28 people, 84.85%
  3. Fall: 28 people, 84.85%
  4. Osteonecrosis Of Jaw (death of bone of jaw): 28 people, 84.85%
  5. Pneumonia: 28 people, 84.85%
  6. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 26 people, 78.79%
  7. Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 26 people, 78.79%
  8. General Physical Health Deterioration (weak health status): 26 people, 78.79%
  9. Spinal Osteoarthritis (joint cartilage loss in spine): 22 people, 66.67%
  10. Atelectasis (partial or complete collapse of the lung): 21 people, 63.64%

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 21 people, 63.64%
  2. Bone Loss: 17 people, 51.52%
  3. Sleep Disorder: 4 people, 12.12%
  4. Upper Respiratory Tract Infection: 2 people, 6.06%
  5. Pain: 2 people, 6.06%
  6. Muscle Spasms (muscle contraction): 2 people, 6.06%
  7. Mood Swings (an extreme or rapid change in mood): 2 people, 6.06%
  8. Metastases To Bone (cancer spreads to bone): 2 people, 6.06%
  9. Dyspnea (difficult or laboured breathing): 2 people, 6.06%
  10. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Seroquel and have Osteolysis?

- Check whether Osteolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Seroquel:

Osteolysis treatments and more:

How severe was Osteolysis and when was it recovered:

Expand to all the drugs that have ingredients of quetiapine fumarate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteolysis:

Browse all the conditions that are associated with Osteolysis:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on quetiapine fumarate (the active ingredients of Seroquel) and Seroquel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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