Sertraline and Bowel movement irregularity - a phase IV clinical study of FDA data

Summary:

Bowel movement irregularity is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Amlodipine, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Bowel movement irregularity when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

What is Bowel movement irregularity?

Bowel movement irregularity is found to be associated with 692 drugs and 629 conditions by eHealthMe. Check the latest studies of Bowel movement irregularity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 82 people (0.06%) have Bowel movement irregularity.

Could Sertraline cause Bowel movement irregularity?

Among these 82 people:

How long have people been on Sertraline when they have Bowel movement irregularity? *

What is the gender of people who have Bowel movement irregularity when taking Sertraline? *

female: 69.44 %
male: 30.56 %

What is the age of people who have Bowel movement irregularity when taking Sertraline? *

What are other drugs people take besides Sertraline? *

What are other side effects people have besides Bowel movement irregularity? *

Diarrhea: 38 people, 46.34%
Nausea (feeling of having an urge to vomit): 36 people, 43.90%
Malaise (a feeling of general discomfort or uneasiness): 35 people, 42.68%
Haematochezia (passage of stools containing blood): 35 people, 42.68%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 35 people, 42.68%
Weakness: 34 people, 41.46%
Chest Pain: 33 people, 40.24%
Abdominal Pain Upper: 33 people, 40.24%
Dyspnea (difficult or laboured breathing): 31 people, 37.80%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 31 people, 37.80%

What are the existing conditions these people have? *

High Blood Cholesterol: 35 people, 42.68%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 28 people, 34.15%
High Blood Pressure: 26 people, 31.71%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 25 people, 30.49%
Heart Attack: 6 people, 7.32%
Blood Pressure Abnormal: 5 people, 6.10%
Amyloidosis (a tumour within which amyloid is produced): 5 people, 6.10%
Thyroid Diseases: 5 people, 6.10%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 6.10%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 4.88%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Bowel movement irregularity?

- Check whether Bowel movement irregularity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,305 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bowel movement irregularity:

Bowel movement irregularity (692 drugs)

Browse all the conditions that are associated with Bowel movement irregularity:

Bowel movement irregularity (629 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.