Sertraline and Multiple cardiac defects - a phase IV clinical study of FDA data

Summary:

Multiple cardiac defects is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for 1 - 6 months also take Prograf, and have Maternal exposure during pregnancy.

The phase IV clinical study analyzes which people have Multiple cardiac defects when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,308 Sertraline users. Check the latest studies of Sertraline.

What is Multiple cardiac defects?

Multiple cardiac defects (more than one heart defects) is found to be associated with 18 drugs and 38 conditions by eHealthMe. Check the latest studies of Multiple cardiac defects.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

146,463 people reported to have side effects when taking Sertraline.
Among them, 14 people (0.01%) have Multiple cardiac defects.

Could Sertraline cause Multiple cardiac defects?

Among these 14 people:

How long have people been on Sertraline when they have Multiple cardiac defects? *

What is the gender of people who have Multiple cardiac defects when taking Sertraline? *

female: 50 %
male: 50 %

What is the age of people who have Multiple cardiac defects when taking Sertraline? *

What are other drugs people take besides Sertraline? *

Azathioprine: 8 people, 57.14%
Prograf: 8 people, 57.14%
Zoloft: 3 people, 21.43%
Insulin: 1 person, 7.14%
Bisoprolol Fumarate: 1 person, 7.14%
Citalopram Hydrobromide: 1 person, 7.14%
Clonazepam: 1 person, 7.14%
Darvocet: 1 person, 7.14%
Fluoxetine: 1 person, 7.14%
Fluvoxamine Maleate: 1 person, 7.14%

What are other side effects people have besides Multiple cardiac defects? *

Maternal Exposure During Pregnancy (use of substance during pregnancy): 4 people, 28.57%
Premature Baby: 2 people, 14.29%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1 person, 7.14%
Drug Exposure During Pregnancy: 1 person, 7.14%
Immunosuppressant Drug Level Decreased: 1 person, 7.14%
Interruption Of Aortic Arch (heart defect in which the aorta is not completely developed): 1 person, 7.14%
Intra-Uterine Death: 1 person, 7.14%
Itching: 1 person, 7.14%
Limb Deformity (functional disability of leg): 1 person, 7.14%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 1 person, 7.14%

What are the existing conditions these people have? *

Maternal Exposure During Pregnancy (use of substance during pregnancy): 5 people, 35.71%
Affective Disorder (mental disorder): 2 people, 14.29%
Urinary Tract Infection: 1 person, 7.14%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 1 person, 7.14%
Drug Exposure During Pregnancy: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Multiple cardiac defects?

- Check whether Multiple cardiac defects is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sertraline (153,308 reports)

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple cardiac defects:

Multiple cardiac defects (18 drugs)

Browse all the conditions that are associated with Multiple cardiac defects:

Multiple cardiac defects (38 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.