Sevoflurane and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Sevoflurane (sevoflurane), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Propofol, and have Hypertonic bladder.

The phase IV clinical study analyzes which people have Headache when taking Sevoflurane. It is created by eHealthMe based on reports of 9,502 people who have side effects when taking Sevoflurane from the FDA, and is updated regularly.

What is Sevoflurane?

Sevoflurane has active ingredients of sevoflurane. eHealthMe is studying from 9,513 Sevoflurane users. Check the latest studies of Sevoflurane.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,775 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 06, 2026

9,502 people reported to have side effects when taking Sevoflurane.
Among them, 52 people (0.55%) have Headache.

Could Sevoflurane cause Headache?

Among these 52 people:

How long have people been on Sevoflurane when they have Headache? *

  • < 1 month: 85.71 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 14.29 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Headache when taking Sevoflurane? *

  • female: 78.26 %
  • male: 21.74 %

What is the age of people who have Headache when taking Sevoflurane? *

  • 0-1: 0.0 %
  • 2-9: 2.27 %
  • 10-19: 6.82 %
  • 20-29: 20.45 %
  • 30-39: 0.0 %
  • 40-49: 34.09 %
  • 50-59: 20.45 %
  • 60+: 15.91 %

What are other drugs people take besides Sevoflurane? *

  1. Propofol: 28 people, 53.85%
  2. Fentanyl: 24 people, 46.15%
  3. Midazolam: 20 people, 38.46%
  4. Gabapentin: 15 people, 28.85%
  5. Ondansetron: 12 people, 23.08%
  6. Baclofen: 11 people, 21.15%
  7. Diazepam: 11 people, 21.15%
  8. Nitrofurantoin: 11 people, 21.15%
  9. Oxybutynin: 11 people, 21.15%
  10. Atropine: 9 people, 17.31%

What are other side effects people have besides Headache? *

  1. High Blood Pressure: 17 people, 32.69%
  2. Nausea (feeling of having an urge to vomit): 17 people, 32.69%
  3. Bradycardia (abnormally slow heart action): 13 people, 25.00%
  4. Heart Rate Decreased: 12 people, 23.08%
  5. Dry Mouth: 12 people, 23.08%
  6. Skin Blushing/flushing (a sudden reddening of the face, neck): 12 people, 23.08%
  7. Rashes (redness): 12 people, 23.08%
  8. Visual Impairment: 11 people, 21.15%
  9. Autonomic Dysreflexia (state that is unique to patients after spinal cord injury at a t-5 level and above): 11 people, 21.15%
  10. Migraine (headache): 7 people, 13.46%

What are the existing conditions these people have? *

  1. Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 11 people, 21.15%
  2. General Anaesthesia: 10 people, 19.23%
  3. Bradycardia (abnormally slow heart action): 9 people, 17.31%
  4. Anaesthesia: 5 people, 9.62%
  5. Pain: 3 people, 5.77%
  6. High Blood Pressure: 3 people, 5.77%
  7. Nausea And Vomiting: 3 people, 5.77%
  8. Nausea (feeling of having an urge to vomit): 3 people, 5.77%
  9. Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 3.85%
  10. Sedation: 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Sevoflurane and have Headache?

- Check whether Headache is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sevoflurane:

Headache treatments and more:

How severe was Headache and when was it recovered:

Expand to all the drugs that have ingredients of sevoflurane:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sevoflurane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Browse all the conditions that are associated with Headache:


How the study uses the data?

The study uses data from the FDA. It is based on sevoflurane (the active ingredients of Sevoflurane) and Sevoflurane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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