Simbrinza and Eyelid oedema - a phase IV clinical study of FDA data

Summary:

Eyelid oedema is reported as a side effect among people who take Simbrinza (brimonidine tartrate; brinzolamide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Alphagan P, and have Intraocular pressure increased.

The phase IV clinical study analyzes which people have Eyelid oedema when taking Simbrinza. It is created by eHealthMe based on reports of 4,527 people who have side effects when taking Simbrinza from the FDA, and is updated regularly.

What is Simbrinza?

Simbrinza has active ingredients of brimonidine tartrate; brinzolamide. It is often used in glaucoma. eHealthMe is studying from 4,543 Simbrinza users. Check the latest studies of Simbrinza.

What is Eyelid oedema?

Eyelid oedema (eyelids are swollen and contain excessive fluid) is found to be associated with 960 drugs and 1,267 conditions by eHealthMe. Check the latest studies of Eyelid oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

4,527 people reported to have side effects when taking Simbrinza.
Among them, 22 people (0.49%) have Eyelid oedema.

Among these 22 people:

How long have people been on Simbrinza when they have Eyelid oedema? *

What is the gender of people who have Eyelid oedema when taking Simbrinza? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Eyelid oedema when taking Simbrinza? *

What are other drugs people take besides Simbrinza? *

What are other side effects people have besides Eyelid oedema? *

Erythema Of Eyelid (redness of the eyelid): 10 people, 45.45%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 7 people, 31.82%
Eye Irritation: 6 people, 27.27%
Eye Pruritus (eye itching): 6 people, 27.27%
Conjunctival Hyperaemia (congestion of conjunctival vessels): 4 people, 18.18%
Eye Pain: 4 people, 18.18%
Eye Swelling: 4 people, 18.18%
Foreign Body Sensation In Eyes (feeling of something in eye): 4 people, 18.18%
Eyelids Pruritus (eyelids itching): 3 people, 13.64%
Hypersensitivity: 3 people, 13.64%

What are the existing conditions these people have? *

Intraocular Pressure Increased: 2 people, 9.09%
Scab (a hard coating on the skin formed during the wound healing): 1 person, 4.55%
Pain: 1 person, 4.55%
Normal Tension Glaucoma (a unique condition in which optic nerve damage and vision loss have occurred despite a normal pressure inside the eye): 1 person, 4.55%
High Blood Pressure: 1 person, 4.55%
Dry Eyes (lack of adequate tears): 1 person, 4.55%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 4.55%
Angle Closure Glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Simbrinza and have Eyelid oedema?

- Check whether Eyelid oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simbrinza:

Simbrinza (4,543 reports)

Eyelid oedema treatments and more:

Eyelid oedema (15,647 reports)

How severe was Eyelid oedema and when was it recovered:

Eyelid oedema in Simbrinza

Expand to all the drugs that have ingredients of brimonidine tartrate; brinzolamide:

Eyelid oedema and drugs with ingredients of brimonidine tartrate; brinzolamide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simbrinza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eyelid oedema:

Eyelid oedema (960 drugs)

Browse all the conditions that are associated with Eyelid oedema:

Eyelid oedema (1,267 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate; brinzolamide (the active ingredients of Simbrinza) and Simbrinza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.