Simbrinza and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Simbrinza (brimonidine tartrate; brinzolamide), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Xolair, and have Asthma.

The phase IV clinical study analyzes which people have Malaise when taking Simbrinza. It is created by eHealthMe based on reports of 4,527 people who have side effects when taking Simbrinza from the FDA, and is updated regularly.

What is Simbrinza?

Simbrinza has active ingredients of brimonidine tartrate; brinzolamide. It is often used in glaucoma. eHealthMe is studying from 4,543 Simbrinza users. Check the latest studies of Simbrinza.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,514 drugs and 5,119 conditions by eHealthMe. Check the latest studies of Malaise.

On Jul, 15, 2026

4,527 people reported to have side effects when taking Simbrinza.
Among them, 91 people (2.01%) have Malaise.

Among these 91 people:

How long have people been on Simbrinza when they have Malaise? *

What is the gender of people who have Malaise when taking Simbrinza? *

female: 44.94 %
male: 55.06 %

What is the age of people who have Malaise when taking Simbrinza? *

What are other drugs people take besides Simbrinza? *

What are other side effects people have besides Malaise? *

Dyspnea (difficult or laboured breathing): 36 people, 39.56%
Fatigue (feeling of tiredness): 30 people, 32.97%
Asthma: 29 people, 31.87%
Body Temperature Decreased: 26 people, 28.57%
Dizziness: 23 people, 25.27%
Nasopharyngitis (inflammation of the nasopharynx): 23 people, 25.27%
Hypotension (abnormally low blood pressure): 21 people, 23.08%
Cough: 21 people, 23.08%
Lung Disorder (lung disease): 20 people, 21.98%
Pneumonia: 18 people, 19.78%

What are the existing conditions these people have? *

Asthma: 28 people, 30.77%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 5.49%
Cardiac Failure Congestive: 3 people, 3.30%
Renal Cell Carcinoma (a kidney cancer): 3 people, 3.30%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 3.30%
Mydriasis (a dilation of the pupil): 2 people, 2.20%
Intraocular Pressure Increased: 2 people, 2.20%
Thyroid Diseases: 2 people, 2.20%
Multiple Myeloma (cancer of the plasma cells): 2 people, 2.20%
Arrhythmias (irregular heartbeat): 2 people, 2.20%

* Approximation only. Some reports may have incomplete information.

Do you take Simbrinza and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simbrinza:

Simbrinza (4,543 reports)

Malaise treatments and more:

Malaise (529,933 reports)

How severe was Malaise and when was it recovered:

Malaise in Simbrinza

Expand to all the drugs that have ingredients of brimonidine tartrate; brinzolamide:

Malaise and drugs with ingredients of brimonidine tartrate; brinzolamide (75 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simbrinza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,514 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,119 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate; brinzolamide (the active ingredients of Simbrinza) and Simbrinza (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.