Sinemet and Thin bones - a phase IV clinical study of FDA data

Summary:

Thin bones is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Zometa, and have Breast cancer.

The phase IV clinical study analyzes which people have Thin bones when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,600 Sinemet users. Check the latest studies of Sinemet.

What is Thin bones?

Thin bones is found to be associated with 2,555 drugs and 1,908 conditions by eHealthMe. Check the latest studies of Thin bones.

On Oct, 31, 2025

28,351 people reported to have side effects when taking Sinemet.
Among them, 120 people (0.42%) have Thin bones.

Among these 120 people:

How long have people been on Sinemet when they have Thin bones? *

What is the gender of people who have Thin bones when taking Sinemet? *

female: 54.62 %
male: 45.38 %

What is the age of people who have Thin bones when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Thin bones? *

Pain: 69 people, 57.50%
Stress And Anxiety: 65 people, 54.17%
Fatigue (feeling of tiredness): 63 people, 52.50%
Headache (pain in head): 60 people, 50.00%
Fall: 57 people, 47.50%
Memory Loss: 53 people, 44.17%
Weakness: 49 people, 40.83%
Dizziness: 49 people, 40.83%
Tremor (trembling or shaking movements in one or more parts of your body): 49 people, 40.83%
Spinal Osteoarthritis (joint cartilage loss in spine): 48 people, 40.00%

What are the existing conditions these people have? *

Breast Cancer: 19 people, 15.83%
Metastases To Bone (cancer spreads to bone): 18 people, 15.00%
Osteopenia (a condition where bone mineral density is lower than normal): 18 people, 15.00%
Type 2 Diabetes: 17 people, 14.17%
Depression: 17 people, 14.17%
Multiple Myeloma (cancer of the plasma cells): 15 people, 12.50%
High Blood Pressure: 15 people, 12.50%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 14 people, 11.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 4.17%
Hiv Infection: 5 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Thin bones?

- Check whether Thin bones is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,600 reports)

Thin bones treatments and more:

Thin bones (290,718 reports)

Common Sinemet side effects:

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Thin bones:

Browse all the drugs that are associated with Thin bones:

Thin bones (2,555 drugs)

Common conditions associated with Thin bones:

Hiv infection: 17,618 reports
Hiv antibody positive: 17,609 reports
Hiv test: 14,475 reports
Ra: 6,348 reports
Osteoporosis: 4,762 reports
Osteopenia: 2,716 reports
Hypertension: 2,532 reports
High blood pressure: 2,527 reports
Pain: 2,496 reports
Alternative medicine - pain relief: 2,492 reports

Browse all the conditions that are associated with Thin bones:

Thin bones (1,908 conditions)

Drugs similar to Sinemet and Thin bones :

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.