Skelaxin and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Skelaxin (metaxalone), especially for people who are female, 60+ old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Anhedonia when taking Skelaxin. It is created by eHealthMe based on reports of 8,840 people who have side effects when taking Skelaxin from the FDA, and is updated regularly.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,512 drugs and 1,274 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Jul, 05, 2026

8,840 people reported to have side effects when taking Skelaxin.
Among them, 160 people (1.81%) have Anhedonia.

Among these 160 people:

* Approximation only. Some reports may have incomplete information.

Do you take Skelaxin and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skelaxin:

Skelaxin (9,706 reports)

Anhedonia treatments and more:

Anhedonia (51,943 reports)

How severe was Anhedonia and when was it recovered:

Anhedonia in Skelaxin

Expand to all the drugs that have ingredients of metaxalone:

Anhedonia and drugs with ingredients of metaxalone (164 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Skelaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,512 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,274 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Skelaxin) and Skelaxin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.