Skelaxin and Mechanical urticaria - a phase IV clinical study of FDA data

Summary:

Mechanical urticaria is reported as a side effect among people who take Skelaxin (metaxalone), especially for people who are female, 30-39 old, also take Nexium, and have Arthritis.

The phase IV clinical study analyzes which people have Mechanical urticaria when taking Skelaxin. It is created by eHealthMe based on reports of 8,840 people who have side effects when taking Skelaxin from the FDA, and is updated regularly.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

What is Mechanical urticaria?

Mechanical urticaria (urticaria is triggered by mechanical shearing forces e.g. stroking or scratching the skin) is found to be associated with 76 drugs and 153 conditions by eHealthMe. Check the latest studies of Mechanical urticaria.

On Jul, 20, 2026

8,840 people reported to have side effects when taking Skelaxin.
Among them, 12 people (0.14%) have Mechanical urticaria.

Could Skelaxin cause Mechanical urticaria?

Among these 12 people:

What is the gender of people who have Mechanical urticaria when taking Skelaxin? *

female: 100 %
male: 0.0 %

What is the age of people who have Mechanical urticaria when taking Skelaxin? *

What are other drugs people take besides Skelaxin? *

What are other side effects people have besides Mechanical urticaria? *

Intervertebral Disc Degeneration (spinal disc degeneration): 12 people, 100.00%
Cyst (a closed sac): 12 people, 100.00%
Hypoaesthesia (reduced sense of touch or sensation): 12 people, 100.00%
Hearing Loss: 12 people, 100.00%
Headache (pain in head): 12 people, 100.00%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 12 people, 100.00%
Genital Rash (rash on sex organ): 12 people, 100.00%
Gastritis (inflammation of stomach): 12 people, 100.00%
Gait Disturbance: 12 people, 100.00%
Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 12 people, 100.00%

What are the existing conditions these people have? *

Pain: 12 people, 100.00%
Hypersensitivity: 12 people, 100.00%
High Blood Cholesterol: 12 people, 100.00%
Headache (pain in head): 12 people, 100.00%
Gastric Ulcer (stomach ulcer): 12 people, 100.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 100.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 100.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 66.67%
Cardiac Disorder: 7 people, 58.33%
Herpes Virus Infection: 6 people, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Skelaxin and have Mechanical urticaria?

- Check whether Mechanical urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skelaxin:

Skelaxin (9,706 reports)

Browse all side effects of Skelaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mechanical urticaria:

Mechanical urticaria (76 drugs)

Browse all the conditions that are associated with Mechanical urticaria:

Mechanical urticaria (153 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Skelaxin) and Skelaxin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.