Skelaxin and Vascular calcification - a phase IV clinical study of FDA data

Summary:

Vascular calcification is reported as a side effect among people who take Skelaxin (metaxalone), especially for people who are female, 50-59 old, also take Celebrex, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Vascular calcification when taking Skelaxin. It is created by eHealthMe based on reports of 8,840 people who have side effects when taking Skelaxin from the FDA, and is updated regularly.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

What is Vascular calcification?

Vascular calcification (deposits of calcium in the blood vessels) is found to be associated with 388 drugs and 419 conditions by eHealthMe. Check the latest studies of Vascular calcification.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

8,840 people reported to have side effects when taking Skelaxin.
Among them, 14 people (0.16%) have Vascular calcification.

Could Skelaxin cause Vascular calcification?

Among these 14 people:

What is the gender of people who have Vascular calcification when taking Skelaxin? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Vascular calcification when taking Skelaxin? *

What are other drugs people take besides Skelaxin? *

Celebrex: 11 people, 78.57%
Pamelor: 10 people, 71.43%
Percocet: 10 people, 71.43%
Vicodin: 9 people, 64.29%
Lopressor: 9 people, 64.29%
Valium: 9 people, 64.29%
Cardizem: 8 people, 57.14%
Soma: 8 people, 57.14%
Tylenol W/ Codeine No. 3: 8 people, 57.14%
Ritalin: 8 people, 57.14%

What are other side effects people have besides Vascular calcification? *

Joint Pain: 13 people, 92.86%
Dizziness: 13 people, 92.86%
Fall: 12 people, 85.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 85.71%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 78.57%
Dyspnea (difficult or laboured breathing): 11 people, 78.57%
High Blood Pressure: 11 people, 78.57%
Depression: 11 people, 78.57%
Pain: 11 people, 78.57%
Spinal Osteoarthritis (joint cartilage loss in spine): 11 people, 78.57%

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 7 people, 50.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 50.00%
Upper Respiratory Tract Infection: 2 people, 14.29%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 14.29%
Pain: 2 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 2 people, 14.29%
Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 2 people, 14.29%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 7.14%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 7.14%
Neoplasm Malignant (cancer tumour): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Skelaxin and have Vascular calcification?

- Check whether Vascular calcification is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Skelaxin:

Skelaxin (9,706 reports)

Browse all side effects of Skelaxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vascular calcification:

Vascular calcification (388 drugs)

Browse all the conditions that are associated with Vascular calcification:

Vascular calcification (419 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metaxalone (the active ingredients of Skelaxin) and Skelaxin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.