Soliqua 100/33 and Peripheral swelling - a phase IV clinical study of FDA data

Summary:

Peripheral swelling is reported as a side effect among people who take Soliqua 100/33 (insulin glargine; lixisenatide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metformin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Peripheral swelling when taking Soliqua 100/33. It is created by eHealthMe based on reports of 2,760 people who have side effects when taking Soliqua 100/33 from the FDA, and is updated regularly.

What is Soliqua 100/33?

Soliqua 100/33 has active ingredients of insulin glargine; lixisenatide. eHealthMe is studying from 2,765 Soliqua 100/33 users. Check the latest studies of Soliqua 100/33.

What is Peripheral swelling?

Peripheral swelling is found to be associated with 2,183 drugs and 1,743 conditions by eHealthMe. Check the latest studies of Peripheral swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

2,760 people reported to have side effects when taking Soliqua 100/33.
Among them, 24 people (0.87%) have Peripheral swelling.

Could Soliqua 100/33 cause Peripheral swelling?

Among these 24 people:

How long have people been on Soliqua 100/33 when they have Peripheral swelling? *

What is the gender of people who have Peripheral swelling when taking Soliqua 100/33? *

female: 59.09 %
male: 40.91 %

What is the age of people who have Peripheral swelling when taking Soliqua 100/33? *

What are other drugs people take besides Soliqua 100/33? *

What are other side effects people have besides Peripheral swelling? *

Weight Increased: 6 people, 25.00%
Blood Glucose Increased: 6 people, 25.00%
Dyspnea (difficult or laboured breathing): 4 people, 16.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 16.67%
Itching: 3 people, 12.50%
Pain In Extremity: 3 people, 12.50%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 8.33%
Back Disorder: 2 people, 8.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 8.33%
Oedema Peripheral (superficial swelling): 2 people, 8.33%

What are the existing conditions these people have? *

Type 2 Diabetes: 7 people, 29.17%
Diabetes: 5 people, 20.83%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 16.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 8.33%
Pain: 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Depression: 2 people, 8.33%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Soliqua 100/33 and have Peripheral swelling?

- Check whether Peripheral swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Soliqua 100/33:

Soliqua 100/33 (2,765 reports)

Peripheral swelling treatments and more:

Peripheral swelling (168,738 reports)

How severe was Peripheral swelling and when was it recovered:

Peripheral swelling in Soliqua 100/33

Expand to all the drugs that have ingredients of insulin glargine; lixisenatide:

Peripheral swelling and drugs with ingredients of insulin glargine; lixisenatide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Soliqua 100/33:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral swelling:

Peripheral swelling (2,183 drugs)

Browse all the conditions that are associated with Peripheral swelling:

Peripheral swelling (1,743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on insulin glargine; lixisenatide (the active ingredients of Soliqua 100/33) and Soliqua 100/33 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.