Spiriva and Aggression - a phase IV clinical study of FDA data

Summary:

Aggression is reported as a side effect among people who take Spiriva (tiotropium bromide monohydrate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Chantix, and have Quit smoking.

The phase IV clinical study analyzes which people have Aggression when taking Spiriva. It is created by eHealthMe based on reports of 155,418 people who have side effects when taking Spiriva from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,665 Spiriva users. Check the latest studies of Spiriva.

What is Aggression?

Aggression is found to be associated with 1,647 drugs and 1,952 conditions by eHealthMe. Check the latest studies of Aggression.

On Oct, 10, 2025

155,418 people reported to have side effects when taking Spiriva.
Among them, 195 people (0.13%) have Aggression.

Among these 195 people:

How long have people been on Spiriva when they have Aggression? *

What is the gender of people who have Aggression when taking Spiriva? *

female: 49.74 %
male: 50.26 %

What is the age of people who have Aggression when taking Spiriva? *

What are other drugs people take besides Spiriva? *

What are other side effects people have besides Aggression? *

Fatigue (feeling of tiredness): 47 people, 24.10%
Sleep Disorder: 46 people, 23.59%
Stress And Anxiety: 43 people, 22.05%
Depression: 38 people, 19.49%
Agitation (state of anxiety or nervous excitement): 36 people, 18.46%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 32 people, 16.41%
Completed Suicide (act of taking one's own life): 30 people, 15.38%
Delirium (wild excitement): 29 people, 14.87%
High Blood Pressure: 29 people, 14.87%
Abnormal Behavior: 28 people, 14.36%

What are the existing conditions these people have? *

Quit Smoking: 42 people, 21.54%
Pneumonia: 29 people, 14.87%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 28 people, 14.36%
Delirium (wild excitement): 28 people, 14.36%
Agitation (state of anxiety or nervous excitement): 25 people, 12.82%
Depression: 24 people, 12.31%
High Blood Pressure: 21 people, 10.77%
Stress And Anxiety: 17 people, 8.72%
Abdominal Pain: 14 people, 7.18%
The Flu (the flu is caused by an influenza virus): 14 people, 7.18%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and have Aggression?

- Check whether Aggression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spiriva:

Spiriva (156,665 reports)

Aggression treatments and more:

Aggression (65,309 reports)

How severe was Aggression and when was it recovered:

Aggression in Spiriva

Expand to all the drugs that have ingredients of tiotropium bromide monohydrate:

Aggression and drugs with ingredients of tiotropium bromide monohydrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Spiriva side effects:

Spiriva side effect: Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe) (7,848 reports)

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Aggression:

Browse all the drugs that are associated with Aggression:

Aggression (1,647 drugs)

Common conditions associated with Aggression:

Browse all the conditions that are associated with Aggression:

Aggression (1,952 conditions)

Drugs similar to Spiriva and Aggression :

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate (the active ingredients of Spiriva) and Spiriva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.