Spironolactone and Dermatomyositis - a phase IV clinical study of FDA data

Summary:

Dermatomyositis is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Adcirca, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Dermatomyositis when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Dermatomyositis?

Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer) is found to be associated with 262 drugs and 416 conditions by eHealthMe. Check the latest studies of Dermatomyositis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 38 people (0.03%) have Dermatomyositis.

Could Spironolactone cause Dermatomyositis?

Among these 38 people:

How long have people been on Spironolactone when they have Dermatomyositis? *

What is the gender of people who have Dermatomyositis when taking Spironolactone? *

female: 43.24 %
male: 56.76 %

What is the age of people who have Dermatomyositis when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Dermatomyositis? *

Device Dislocation: 10 people, 26.32%
Diarrhea: 10 people, 26.32%
Troponin Increased: 10 people, 26.32%
Dyspnea (difficult or laboured breathing): 10 people, 26.32%
Fever: 10 people, 26.32%
Sinusitis (inflammation of sinus): 10 people, 26.32%
Myocarditis (inflammation of heart muscle myocardium): 9 people, 23.68%
Wound: 6 people, 15.79%
Pain: 6 people, 15.79%
Dyspnea Exertional: 6 people, 15.79%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 26.32%
High Blood Cholesterol: 6 people, 15.79%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 7.89%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 2 people, 5.26%
Nausea (feeling of having an urge to vomit): 2 people, 5.26%
Hypoaesthesia (reduced sense of touch or sensation): 2 people, 5.26%
Diarrhea: 2 people, 5.26%
Cancer Pain: 2 people, 5.26%
Ascites (accumulation of fluid in the abdominal cavity): 2 people, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Dermatomyositis?

- Check whether Dermatomyositis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Dermatomyositis treatments and more:

Dermatomyositis (8,399 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dermatomyositis:

Dermatomyositis (262 drugs)

Browse all the conditions that are associated with Dermatomyositis:

Dermatomyositis (416 conditions)

Related publications that referenced our studies

Kato, M., Oiso, N., Nozaki, Y., Inoue, A., Hosono, Y., Funauchi, M., ... & Kawada, A., "Antitumor necrosis factor alpha inhibitor‐induced dermatomyositis and interstitial lung disease with anti‐PL 12 autoantibody: Signs of antisynthetase syndrome", The Journal of dermatology, 2012 Jan .
Kato, M., Oiso, N., Nozaki, Y., Inoue, A., Hosono, Y., Funauchi, M., ... & Kawada, A., "Antitumor necrosis factor alpha inhibitor‐induced dermatomyositis and interstitial lung disease with anti‐PL 12 autoantibody: Signs of antisynthetase syndrome", The Journal of dermatology, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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