Spironolactone and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lasix, and have Systemic lupus erythematosus.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,946 Spironolactone users. Check the latest studies of Spironolactone.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 398 drugs and 537 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On May, 22, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 24 people (0.02%) have Hypercoagulation.

Could Spironolactone cause Hypercoagulation?

Among these 24 people:

How long have people been on Spironolactone when they have Hypercoagulation? *

What is the gender of people who have Hypercoagulation when taking Spironolactone? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Hypercoagulation when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Hypercoagulation? *

Pain: 7 people, 29.17%
Acute Kidney Failure: 7 people, 29.17%
Dyspnea (difficult or laboured breathing): 6 people, 25.00%
Headache (pain in head): 6 people, 25.00%
Fever: 6 people, 25.00%
Dizziness: 6 people, 25.00%
Chills (felling of cold): 5 people, 20.83%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 20.83%
Fatigue (feeling of tiredness): 5 people, 20.83%
Pain In Extremity: 5 people, 20.83%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 16.67%
Speech Impairment (Adult) (inability to speak (adult)): 3 people, 12.50%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 12.50%
Renal Cell Carcinoma (a kidney cancer): 2 people, 8.33%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 8.33%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 4.17%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 4.17%
Enlarged Prostate: 1 person, 4.17%
Duodenal Ulcer Haemorrhage (bleeding duodenal ulcer): 1 person, 4.17%
Diabetic Gastroparesis (paralysis of the muscles of the stomach caused by diabetes): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Hypercoagulation?

- Check whether Hypercoagulation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,946 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (398 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (537 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.