Spironolactone and Hysterectomy - a phase IV clinical study of FDA data

Summary:

Hysterectomy is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Hysterectomy when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Hysterectomy?

Hysterectomy is found to be associated with 716 drugs and 1,377 conditions by eHealthMe. Check the latest studies of Hysterectomy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 72 people (0.06%) have Hysterectomy.

Could Spironolactone cause Hysterectomy?

Among these 72 people:

How long have people been on Spironolactone when they have Hysterectomy? *

What is the gender of people who have Hysterectomy when taking Spironolactone? *

female: 96.92 %
male: 3.08 %

What is the age of people who have Hysterectomy when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Hysterectomy? *

Dyspnea (difficult or laboured breathing): 16 people, 22.22%
Headache (pain in head): 14 people, 19.44%
Depression: 11 people, 15.28%
Chest Pain: 10 people, 13.89%
Vaginal Bleeding: 10 people, 13.89%
Urinary Tract Infection: 10 people, 13.89%
Nausea And Vomiting: 10 people, 13.89%
Anaemia (lack of blood): 9 people, 12.50%
Nasopharyngitis (inflammation of the nasopharynx): 8 people, 11.11%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 8 people, 11.11%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 38.89%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 20.83%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 11 people, 15.28%
Insomnia (sleeplessness): 7 people, 9.72%
Chest Pain: 7 people, 9.72%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 7 people, 9.72%
Drowsiness: 7 people, 9.72%
Cushing's Syndrome (obesity, a rounded face, increased fat): 5 people, 6.94%
Osteoporosis (bones weak and more likely to break): 4 people, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Hysterectomy?

- Check whether Hysterectomy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Hysterectomy treatments and more:

Hysterectomy (13,002 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hysterectomy:

Hysterectomy (716 drugs)

Browse all the conditions that are associated with Hysterectomy:

Hysterectomy (1,377 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.