Spironolactone and Transfusion reaction - a phase IV clinical study of FDA data

Summary:

Transfusion reaction is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 50-59 old, also take Lactulose, and have Idiopathic thrombocytopenic purpura.

The phase IV clinical study analyzes which people have Transfusion reaction when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Transfusion reaction?

Transfusion reaction (a serious problem that occurs after a patient receives a transfusion of blood) is found to be associated with 168 drugs and 405 conditions by eHealthMe. Check the latest studies of Transfusion reaction.

On Jul, 12, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 23 people (0.02%) have Transfusion reaction.

Could Spironolactone cause Transfusion reaction?

Among these 23 people:

What is the gender of people who have Transfusion reaction when taking Spironolactone? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Transfusion reaction when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Transfusion reaction? *

Dyspnea (difficult or laboured breathing): 9 people, 39.13%
Anaemia (lack of blood): 7 people, 30.43%
Oedema (fluid collection in tissue): 6 people, 26.09%
Acute Kidney Failure: 6 people, 26.09%
Fluid Overload (too much fluid in the blood): 6 people, 26.09%
Brain Natriuretic Peptide Increased: 6 people, 26.09%
Renal Tubular Necrosis (death of kidney tubules): 5 people, 21.74%
Pleural Effusion (water on the lungs): 5 people, 21.74%
Pain In Extremity: 5 people, 21.74%
Blood Bilirubin Increased: 5 people, 21.74%

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 5 people, 21.74%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 17.39%
Cardiac Disorder: 4 people, 17.39%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 13.04%
Hypovolaemia (a decreased volume of circulating blood in the body): 2 people, 8.70%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 8.70%
Type 2 Diabetes: 1 person, 4.35%
Chronic Renal Failure (kidney failure): 1 person, 4.35%
Diabetes: 1 person, 4.35%
Electrolyte Imbalance: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Transfusion reaction?

- Check whether Transfusion reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Transfusion reaction:

Transfusion reaction (168 drugs)

Browse all the conditions that are associated with Transfusion reaction:

Transfusion reaction (405 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.