Spironolactone and Ureteric obstruction - a phase IV clinical study of FDA data

Summary:

Ureteric obstruction is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Digoxin, and have Breast cancer.

The phase IV clinical study analyzes which people have Ureteric obstruction when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Ureteric obstruction?

Ureteric obstruction is found to be associated with 348 drugs and 362 conditions by eHealthMe. Check the latest studies of Ureteric obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 28 people (0.02%) have Ureteric obstruction.

Could Spironolactone cause Ureteric obstruction?

Among these 28 people:

How long have people been on Spironolactone when they have Ureteric obstruction? *

What is the gender of people who have Ureteric obstruction when taking Spironolactone? *

female: 81.48 %
male: 18.52 %

What is the age of people who have Ureteric obstruction when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Ureteric obstruction? *

Unilateral Hydronephrosis (kidney stone that causes obstruction of the ureter): 14 people, 50.00%
Fall: 14 people, 50.00%
Ascites (accumulation of fluid in the abdominal cavity): 11 people, 39.29%
Impaired Healing: 11 people, 39.29%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 11 people, 39.29%
Splenomegaly (enlargement of spleen): 11 people, 39.29%
Stress And Anxiety: 11 people, 39.29%
Osteomyelitis (infection of bone): 11 people, 39.29%
Emotional Distress: 11 people, 39.29%
Pain: 11 people, 39.29%

What are the existing conditions these people have? *

Breast Cancer: 12 people, 42.86%
Cardiac Failure: 9 people, 32.14%
Stress And Anxiety: 7 people, 25.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 25.00%
Hyperlipidaemia (presence of excess lipids in the blood): 7 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 25.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 25.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 25.00%
Metastases To Bone (cancer spreads to bone): 6 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Ureteric obstruction?

- Check whether Ureteric obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ureteric obstruction:

Ureteric obstruction (348 drugs)

Browse all the conditions that are associated with Ureteric obstruction:

Ureteric obstruction (362 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.