Spravato and Heart palpitations - a phase IV clinical study of FDA data

Summary:

Heart palpitations is reported as a side effect among people who take Spravato (esketamine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Gabapentin, and have Depression.

The phase IV clinical study analyzes which people have Heart palpitations when taking Spravato. It is created by eHealthMe based on reports of 7,912 people who have side effects when taking Spravato from the FDA, and is updated regularly.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

What is Heart palpitations?

Heart palpitations (feelings or sensations that your heart is pounding or racing) is found to be associated with 2,437 drugs and 3,638 conditions by eHealthMe. Check the latest studies of Heart palpitations.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

7,912 people reported to have side effects when taking Spravato.
Among them, 24 people (0.3%) have Heart palpitations.

Could Spravato cause Heart palpitations?

Among these 24 people:

How long have people been on Spravato when they have Heart palpitations? *

What is the gender of people who have Heart palpitations when taking Spravato? *

female: 86.96 %
male: 13.04 %

What is the age of people who have Heart palpitations when taking Spravato? *

What are other drugs people take besides Spravato? *

Gabapentin: 4 people, 16.67%
Lansoprazole: 3 people, 12.50%
Synthroid: 3 people, 12.50%
Clonazepam: 2 people, 8.33%
Cymbalta: 2 people, 8.33%
Escitalopram: 2 people, 8.33%
Lamictal: 2 people, 8.33%
Zofran: 2 people, 8.33%
Adderall: 2 people, 8.33%
Ropinirole Hydrochloride: 1 person, 4.17%

What are other side effects people have besides Heart palpitations? *

Dissociation: 8 people, 33.33%
Stress And Anxiety: 6 people, 25.00%
High Blood Pressure: 5 people, 20.83%
Chest Pain: 4 people, 16.67%
Dyspnea (difficult or laboured breathing): 4 people, 16.67%
Dizziness: 4 people, 16.67%
Fatigue (feeling of tiredness): 3 people, 12.50%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 12.50%
Depression: 3 people, 12.50%
Insomnia (sleeplessness): 3 people, 12.50%

What are the existing conditions these people have? *

Depression: 16 people, 66.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 20.83%
Tardive Dyskinesia (a disorder that involves involuntary movements): 2 people, 8.33%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 2 people, 8.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 8.33%
Stress And Anxiety: 1 person, 4.17%
Pain: 1 person, 4.17%
Irritable Bowel Syndrome: 1 person, 4.17%
Insomnia (sleeplessness): 1 person, 4.17%
High Blood Pressure: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Spravato and have Heart palpitations?

- Check whether Heart palpitations is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spravato:

Spravato (7,920 reports)

Browse all side effects of Spravato:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart palpitations:

Heart palpitations (2,437 drugs)

Browse all the conditions that are associated with Heart palpitations:

Heart palpitations (3,638 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on esketamine hydrochloride (the active ingredients of Spravato) and Spravato (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.