Sprintec and Intermenstrual bleeding - a phase IV clinical study of FDA data

Summary:

Intermenstrual bleeding is reported as a side effect among people who take Sprintec (ethinyl estradiol; norgestimate), especially for people who are 20-29 old, have been taking the drug for 1 - 6 months also take Previfem, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Intermenstrual bleeding when taking Sprintec. It is created by eHealthMe based on reports of 3,556 people who have side effects when taking Sprintec from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Intermenstrual bleeding?

Intermenstrual bleeding is found to be associated with 1,083 drugs and 1,514 conditions by eHealthMe. Check the latest studies of Intermenstrual bleeding.

On Oct, 18, 2025

3,556 people reported to have side effects when taking Sprintec.
Among them, 62 people (1.74%) have Intermenstrual bleeding.

Could Sprintec cause Intermenstrual bleeding?

Among these 62 people:

How long have people been on Sprintec when they have Intermenstrual bleeding? *

What is the age of people who have Intermenstrual bleeding when taking Sprintec? *

What are other drugs people take besides Sprintec? *

What are other side effects people have besides Intermenstrual bleeding? *

Muscle Spasms (muscle contraction): 6 people, 9.68%
Menstruation Irregular: 6 people, 9.68%
Weight Increased: 5 people, 8.06%
Mood Swings (an extreme or rapid change in mood): 5 people, 8.06%
Heavy Or Prolong Menstrual Bleeding: 5 people, 8.06%
Nausea (feeling of having an urge to vomit): 5 people, 8.06%
Depression: 4 people, 6.45%
Headache (pain in head): 4 people, 6.45%
Fatigue (feeling of tiredness): 4 people, 6.45%
Drug Ineffective: 3 people, 4.84%

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 4.84%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 3.23%
Pain: 2 people, 3.23%
Ovarian Cysts (fluid filled sacs of the ovary): 2 people, 3.23%
Insomnia (sleeplessness): 2 people, 3.23%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 1.61%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 1 person, 1.61%
Dysmenorrhea (painful menstruation): 1 person, 1.61%
Disease Progression: 1 person, 1.61%
Blood Uric Acid Increased: 1 person, 1.61%

* Approximation only. Some reports may have incomplete information.

Do you take Sprintec and have Intermenstrual bleeding?

- Check whether Intermenstrual bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sprintec:

Sprintec (4,397 reports)

Intermenstrual bleeding treatments and more:

Intermenstrual bleeding (26,952 reports)

How severe was Intermenstrual bleeding and when was it recovered:

Intermenstrual bleeding in Sprintec

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Intermenstrual bleeding and drugs with ingredients of ethinyl estradiol; norgestimate (511 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intermenstrual bleeding:

Intermenstrual bleeding (1,083 drugs)

Browse all the conditions that are associated with Intermenstrual bleeding:

Intermenstrual bleeding (1,514 conditions)

Drugs similar to Sprintec and Intermenstrual bleeding :

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Sprintec) and Sprintec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.