Depo-provera and Intermenstrual bleeding - a phase IV clinical study of FDA data

Summary:

Intermenstrual bleeding is reported as a side effect among people who take Depo-provera (medroxyprogesterone acetate), especially for people who are 20-29 old, have been taking the drug for < 1 month also take Lamictal, and have Menstrual discomfort.

The phase IV clinical study analyzes which people have Intermenstrual bleeding when taking Depo-provera. It is created by eHealthMe based on reports of 15,804 people who have side effects when taking Depo-provera from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Intermenstrual bleeding?

Intermenstrual bleeding is found to be associated with 1,059 drugs and 1,519 conditions by eHealthMe. Check the latest studies of Intermenstrual bleeding.

On Dec, 10, 2025

15,804 people reported to have side effects when taking Depo-provera.
Among them, 620 people (3.92%) have Intermenstrual bleeding.

Could Depo-provera cause Intermenstrual bleeding?

Among these 620 people:

How long have people been on Depo-provera when they have Intermenstrual bleeding? *

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What is the age of people who have Intermenstrual bleeding when taking Depo-provera? *

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* Approximation only. Some reports may have incomplete information.

Do you take Depo-provera and have Intermenstrual bleeding?

- Check whether Intermenstrual bleeding is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depo-provera:

Depo-provera (17,093 reports)

Intermenstrual bleeding treatments and more:

Intermenstrual bleeding (26,953 reports)

How severe was Intermenstrual bleeding and when was it recovered:

Intermenstrual bleeding in Depo-provera

Expand to all the drugs that have ingredients of medroxyprogesterone acetate:

Intermenstrual bleeding and drugs with ingredients of medroxyprogesterone acetate (865 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Depo-provera side effects:

Browse all side effects of Depo-provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Intermenstrual bleeding:

Browse all the drugs that are associated with Intermenstrual bleeding:

Intermenstrual bleeding (1,059 drugs)

Common conditions associated with Intermenstrual bleeding:

Contraception: 11,750 reports
Family planning and contraception: 10,081 reports
Endometriosis: 485 reports
Antidepressant therapy: 308 reports
Heavy or prolong menstrual bleeding: 292 reports
Oral contraception: 284 reports
Multiple sclerosis: 254 reports
Uterine leiomyoma: 239 reports
Menstruation irregular: 227 reports
Migraine aggravated: 222 reports

Browse all the conditions that are associated with Intermenstrual bleeding:

Intermenstrual bleeding (1,519 conditions)

Drugs similar to Depo-provera and Intermenstrual bleeding :

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Depo-provera) and Depo-provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.