Sprintec and Ra - a phase IV clinical study of FDA data

Summary:

Ra is reported as a side effect among people who take Sprintec (ethinyl estradiol; norgestimate), especially for people who are female, 20-29 old, have been taking the drug for 10+ years also take Cimzia, and have Narcolepsy.

The phase IV clinical study analyzes which people have Ra when taking Sprintec. It is created by eHealthMe based on reports of 3,556 people who have side effects when taking Sprintec from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Ra?

Ra (rheumatoid arthritis) is found to be associated with 1,618 drugs and 2,085 conditions by eHealthMe. Check the latest studies of Ra.

On Jul, 30, 2025

3,556 people reported to have side effects when taking Sprintec.
Among them, 18 people (0.51%) have Ra.

Among these 18 people:

How long have people been on Sprintec when they have Ra? *

What is the gender of people who have Ra when taking Sprintec? *

female: 100 %
male: 0.0 %

What is the age of people who have Ra when taking Sprintec? *

What are other drugs people take besides Sprintec? *

Cimzia: 8 people, 44.44%
Xyrem: 6 people, 33.33%
Flonase Allergy Relief: 6 people, 33.33%
Zofran: 5 people, 27.78%
Adderall: 4 people, 22.22%
Humira: 4 people, 22.22%
Cymbalta: 3 people, 16.67%
Methotrexate: 3 people, 16.67%
Sertraline Hydrochloride: 2 people, 11.11%
Nuvigil: 2 people, 11.11%

What are other side effects people have besides Ra? *

Pain: 5 people, 27.78%
Gait Disturbance: 4 people, 22.22%
Muscle Spasms (muscle contraction): 4 people, 22.22%
Therapeutic Response Decreased (less preventive response): 2 people, 11.11%
Skin Discoloration: 2 people, 11.11%
Peripheral Swelling: 2 people, 11.11%
Pain In Jaw: 2 people, 11.11%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 2 people, 11.11%
Bruxism (habitual grinding of the teeth, typically during sleep): 2 people, 11.11%
Drug Ineffective: 1 person, 5.56%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 33.33%
Tension Headache: 3 people, 16.67%
Headache (pain in head): 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Stress And Anxiety: 1 person, 5.56%
Migraine (headache): 1 person, 5.56%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 5.56%
Drowsiness: 1 person, 5.56%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Sprintec and have Ra?

- Check whether Ra is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sprintec:

Sprintec (4,397 reports)

Ra treatments and more:

Ra (1,091,813 reports)

How severe was Ra and when was it recovered:

Ra in Sprintec

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Ra and drugs with ingredients of ethinyl estradiol; norgestimate (53 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ra:

Ra (1,618 drugs)

Browse all the conditions that are associated with Ra:

Ra (2,085 conditions)

Drugs similar to Sprintec and Ra :

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Sprintec) and Sprintec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.