Sprix and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Sprix (ketorolac tromethamine), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Botox, and have Migraine.

The phase IV clinical study analyzes which people have Headache when taking Sprix. It is created by eHealthMe based on reports of 610 people who have side effects when taking Sprix from the FDA, and is updated regularly.

What is Sprix?

Sprix has active ingredients of ketorolac tromethamine. eHealthMe is studying from 616 Sprix users. Check the latest studies of Sprix.

What is Headache?

Headache (pain in head) is found to be associated with 3,751 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 19, 2026

610 people reported to have side effects when taking Sprix.
Among them, 25 people (4.1%) have Headache.

Among these 25 people:

How long have people been on Sprix when they have Headache? *

What is the gender of people who have Headache when taking Sprix? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Headache when taking Sprix? *

What are other drugs people take besides Sprix? *

What are other side effects people have besides Headache? *

Migraine (headache): 7 people, 28.00%
Gastritis (inflammation of stomach): 5 people, 20.00%
Feeling Abnormal: 5 people, 20.00%
Heart Rate Decreased: 5 people, 20.00%
Heart Rate Increased: 5 people, 20.00%
Hypotension (abnormally low blood pressure): 5 people, 20.00%
Pancreatitis (inflammation of pancreas): 5 people, 20.00%
Tumor: 4 people, 16.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 16.00%
Nausea (feeling of having an urge to vomit): 4 people, 16.00%

What are the existing conditions these people have? *

Migraine (headache): 12 people, 48.00%
Pain: 4 people, 16.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 8.00%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 4.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.00%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 4.00%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 4.00%
Nausea (feeling of having an urge to vomit): 1 person, 4.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.00%
Muscle Spasms (muscle contraction): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sprix and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sprix:

Sprix (616 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Sprix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,751 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,772 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ketorolac tromethamine (the active ingredients of Sprix) and Sprix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.