St. john's wort and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take St. john's wort (st. john's wort), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Plavix, and have Arrhythmias.

The phase IV clinical study analyzes which people have Pain when taking St. john's wort. It is created by eHealthMe based on reports of 586 people who have side effects when taking St. john's wort from the FDA, and is updated regularly.

What is St. john's wort?

St. john's wort has active ingredients of st. john's wort. It is often used in depression. eHealthMe is studying from 697 St. john's wort users. Check the latest studies of St. john's wort.

What is Pain?

Pain is found to be associated with 3,816 drugs and 5,866 conditions by eHealthMe. Check the latest studies of Pain.

On Jul, 17, 2026

586 people reported to have side effects when taking St. john's wort.
Among them, 72 people (12.29%) have Pain.

Among these 72 people:

How long have people been on St. john's wort when they have Pain? *

What is the gender of people who have Pain when taking St. john's wort? *

female: 59.72 %
male: 40.28 %

What is the age of people who have Pain when taking St. john's wort? *

What are other drugs people take besides St. john's wort? *

What are other side effects people have besides Pain? *

Insomnia (sleeplessness): 37 people, 51.39%
Neuropathy Peripheral (surface nerve damage): 34 people, 47.22%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 34 people, 47.22%
Enlarged Heart: 34 people, 47.22%
Oedema Peripheral (superficial swelling): 33 people, 45.83%
Dyspnea Exertional: 30 people, 41.67%
Back Pain: 30 people, 41.67%
Fall: 29 people, 40.28%
Foot Deformity (functional disability of foot): 29 people, 40.28%
Osteopenia (a condition where bone mineral density is lower than normal): 28 people, 38.89%

What are the existing conditions these people have? *

Arrhythmias (irregular heartbeat): 22 people, 30.56%
Multiple Myeloma (cancer of the plasma cells): 21 people, 29.17%
Stable Angina (a constant chest pain): 21 people, 29.17%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 21 people, 29.17%
Bone Density Abnormal: 11 people, 15.28%
Birth Control: 10 people, 13.89%
Premenstrual Syndrome: 8 people, 11.11%
Osteoporosis (bones weak and more likely to break): 6 people, 8.33%
Acne (skin problems that cause pimples): 4 people, 5.56%
Affective Disorder (mental disorder): 3 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take St. john's wort and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to St. john's wort:

St. john's wort (697 reports)

Pain treatments and more:

Pain (1,140,594 reports)

Browse all side effects of St. john's wort:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,816 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,866 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on st. john's wort (the active ingredients of St. john's wort) and St. john's wort (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.