Suboxone and Burning sensation - a phase IV clinical study of FDA data


We study 27,533 people who have side effects when taking Suboxone. Burning sensation is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Cymbalta and have Drug dependence.

The phase IV clinical study analyzes which people take Suboxone and have Burning sensation. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 03, 2023

27,533 people reported to have side effects when taking Suboxone.
Among them, 80 people (0.29%) have Burning sensation.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is used in opiate withdrawal. Currently, eHealthMe is studying from 30,412 Suboxone users.

What is Burning sensation?

Burning sensation is found to be associated with 2,774 drugs and 2,039 conditions by eHealthMe. Currently, we are studying 75,727 people who have Burning sensation.

Number of Suboxone and Burning sensation reports submitted per year:

Could Suboxone cause Burning sensation?

Time on Suboxone when people have Burning sensation *:

  • < 1 month: 38.46 %
  • 1 - 6 months: 53.85 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 7.69 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Burning sensation when taking Suboxone *:

  • female: 63.93 %
  • male: 36.07 %

Age of people who have Burning sensation when taking Suboxone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 9.43 %
  • 30-39: 20.75 %
  • 40-49: 20.75 %
  • 50-59: 13.21 %
  • 60+: 35.85 %

Common drugs people take besides Suboxone *:

  1. Synthroid: 10 people, 12.50%
  2. Lyrica: 10 people, 12.50%
  3. Cymbalta: 10 people, 12.50%
  4. Neurontin: 6 people, 7.50%
  5. Xanax: 6 people, 7.50%
  6. Zocor: 5 people, 6.25%
  7. Denavir: 4 people, 5.00%
  8. Aleve: 4 people, 5.00%
  9. Climara Pro: 4 people, 5.00%
  10. Zoloft: 4 people, 5.00%

Common side effects people have besides Burning sensation *:

  1. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 17 people, 21.25%
  2. Pain: 17 people, 21.25%
  3. Itching: 13 people, 16.25%
  4. Headache (pain in head): 12 people, 15.00%
  5. Feeling Abnormal: 12 people, 15.00%
  6. Nausea (feeling of having an urge to vomit): 11 people, 13.75%
  7. Insomnia (sleeplessness): 11 people, 13.75%
  8. Drug Dependence: 10 people, 12.50%
  9. Drug Ineffective: 9 people, 11.25%
  10. Rashes (redness): 9 people, 11.25%

Common conditions people have *:

  1. Drug Dependence: 30 people, 37.50%
  2. Pain: 13 people, 16.25%
  3. Neuralgia (pain in one or more nerves): 8 people, 10.00%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 7.50%
  5. Immunodeficiency Common Variable: 4 people, 5.00%
  6. Musculoskeletal Discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 3 people, 3.75%
  7. Back Disorder: 3 people, 3.75%
  8. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 3.75%
  9. Depression: 3 people, 3.75%
  10. Insomnia (sleeplessness): 3 people, 3.75%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Burning sensation?

Check whether Burning sensation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Suboxone side effects by duration, gender and age:

Burning sensation treatments and more:

Common drugs associated with Burning sensation:

All the drugs that are associated with Burning sensation:

Common conditions associated with Burning sensation:

All the conditions that are associated with Burning sensation:

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone) and Suboxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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