Suboxone and Hip joint replacement - a phase IV clinical study of FDA data

Summary:

Hip joint replacement is reported as a side effect among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Saxenda, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Hip joint replacement when taking Suboxone. It is created by eHealthMe based on reports of 28,308 people who have side effects when taking Suboxone from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Hip joint replacement?

Hip joint replacement is found to be associated with 861 drugs and 1,062 conditions by eHealthMe. Check the latest studies of Hip joint replacement.

On Jul, 10, 2026

28,308 people reported to have side effects when taking Suboxone.
Among them, 16 people (0.06%) have Hip joint replacement.

Could Suboxone cause Hip joint replacement?

Among these 16 people:

How long have people been on Suboxone when they have Hip joint replacement? *

What is the gender of people who have Hip joint replacement when taking Suboxone? *

female: 50 %
male: 50 %

What is the age of people who have Hip joint replacement when taking Suboxone? *

What are other drugs people take besides Suboxone? *

What are other side effects people have besides Hip joint replacement? *

Pneumonia: 5 people, 31.25%
Stress And Anxiety: 5 people, 31.25%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 5 people, 31.25%
Road Traffic Accident: 5 people, 31.25%
Injection Site Abscess: 4 people, 25.00%
Infusion Site Extravasation (flow of (blood or lymph) from infusion site): 4 people, 25.00%
Joint Dislocation Postoperative (a joint position is changed from normal position after operation): 3 people, 18.75%
Mobility Decreased (ability to move is reduced): 3 people, 18.75%
Osteoporosis (bones weak and more likely to break): 3 people, 18.75%
Pain: 3 people, 18.75%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 31.25%
Pain: 3 people, 18.75%
Hiv Infection: 3 people, 18.75%
Stress And Anxiety: 2 people, 12.50%
Road Traffic Accident: 2 people, 12.50%
Neck Pain: 2 people, 12.50%
Migraine (headache): 2 people, 12.50%
Joint Pain: 2 people, 12.50%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 12.50%
Abdominal Discomfort: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Hip joint replacement?

- Check whether Hip joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Suboxone:

Suboxone (31,249 reports)

Hip joint replacement treatments and more:

Hip joint replacement (20,106 reports)

How severe was Hip joint replacement and when was it recovered:

Hip joint replacement in Suboxone

Expand to all the drugs that have ingredients of buprenorphine hydrochloride; naloxone hydrochloride:

Hip joint replacement and drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride (18 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Suboxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hip joint replacement:

Hip joint replacement (861 drugs)

Browse all the conditions that are associated with Hip joint replacement:

Hip joint replacement (1,062 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone) and Suboxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.