Suboxone and Osteoarthritis aggravated - a phase IV clinical study of FDA data

Summary:

Osteoarthritis aggravated is reported as a side effect among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Dilaudid, and have Drug dependence.

The phase IV clinical study analyzes which people have Osteoarthritis aggravated when taking Suboxone. It is created by eHealthMe based on reports of 28,308 people who have side effects when taking Suboxone from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,250 Suboxone users. Check the latest studies of Suboxone.

What is Osteoarthritis aggravated?

Osteoarthritis aggravated (joint disease caused by cartilage loss in a joint) is found to be associated with 1,334 drugs and 386 conditions by eHealthMe. Check the latest studies of Osteoarthritis aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

28,308 people reported to have side effects when taking Suboxone.
Among them, 47 people (0.17%) have Osteoarthritis aggravated.

Could Suboxone cause Osteoarthritis aggravated?

Among these 47 people:

How long have people been on Suboxone when they have Osteoarthritis aggravated? *

What is the gender of people who have Osteoarthritis aggravated when taking Suboxone? *

female: 65.85 %
male: 34.15 %

What is the age of people who have Osteoarthritis aggravated when taking Suboxone? *

What are other drugs people take besides Suboxone? *

What are other side effects people have besides Osteoarthritis aggravated? *

Pain: 19 people, 40.43%
Fatigue (feeling of tiredness): 14 people, 29.79%
Back Pain: 12 people, 25.53%
Stress And Anxiety: 11 people, 23.40%
Insomnia (sleeplessness): 11 people, 23.40%
Depression: 10 people, 21.28%
Suicidal Ideation: 9 people, 19.15%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 19.15%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 9 people, 19.15%
Herpes Zoster: 9 people, 19.15%

What are the existing conditions these people have? *

Drug Dependence: 12 people, 25.53%
Pain: 8 people, 17.02%
Depression: 7 people, 14.89%
Stress And Anxiety: 5 people, 10.64%
High Blood Pressure: 3 people, 6.38%
Immunodeficiency Common Variable: 3 people, 6.38%
Primary Immunodeficiency Syndrome: 3 people, 6.38%
Osteoporosis (bones weak and more likely to break): 2 people, 4.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 4.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Osteoarthritis aggravated?

- Check whether Osteoarthritis aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Suboxone:

Suboxone (31,250 reports)

Osteoarthritis aggravated treatments and more:

Osteoarthritis aggravated (99 reports)

How severe was Osteoarthritis aggravated and when was it recovered:

Osteoarthritis aggravated in Suboxone

Expand to all the drugs that have ingredients of buprenorphine hydrochloride; naloxone hydrochloride:

Osteoarthritis aggravated and drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Suboxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis aggravated:

Osteoarthritis aggravated (1,334 drugs)

Browse all the conditions that are associated with Osteoarthritis aggravated:

Osteoarthritis aggravated (386 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone) and Suboxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.