Suboxone and Spinal fusion surgery - a phase IV clinical study of FDA data

Summary:

Spinal fusion surgery is reported as a side effect among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride), especially for people who are male, 40-49 old, also take Oxycontin, and have Pain.

The phase IV clinical study analyzes which people have Spinal fusion surgery when taking Suboxone. It is created by eHealthMe based on reports of 28,308 people who have side effects when taking Suboxone from the FDA, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Spinal fusion surgery?

Spinal fusion surgery is found to be associated with 493 drugs and 422 conditions by eHealthMe. Check the latest studies of Spinal fusion surgery.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

28,308 people reported to have side effects when taking Suboxone.
Among them, 12 people (0.04%) have Spinal fusion surgery.

Could Suboxone cause Spinal fusion surgery?

Among these 12 people:

What is the gender of people who have Spinal fusion surgery when taking Suboxone? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Spinal fusion surgery when taking Suboxone? *

What are other drugs people take besides Suboxone? *

Oxycontin: 10 people, 83.33%
Dilaudid: 6 people, 50.00%
Hydrocodone Bitartrate And Acetaminophen: 5 people, 41.67%
Ambien: 4 people, 33.33%
Valium: 4 people, 33.33%
Norco: 4 people, 33.33%
Percocet: 3 people, 25.00%
Cymbalta: 3 people, 25.00%
Darvocet: 3 people, 25.00%
Lortab: 3 people, 25.00%

What are other side effects people have besides Spinal fusion surgery? *

Stress And Anxiety: 9 people, 75.00%
Overdose: 8 people, 66.67%
Drug Dependence: 6 people, 50.00%
Intervertebral Disc Operation: 6 people, 50.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 41.67%
Insomnia (sleeplessness): 4 people, 33.33%
Localised Infection (infection at the single location): 4 people, 33.33%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 4 people, 33.33%
Cubital Tunnel Syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow): 4 people, 33.33%
Fatigue (feeling of tiredness): 4 people, 33.33%

What are the existing conditions these people have? *

Pain: 6 people, 50.00%
Migraine (headache): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Spinal fusion surgery?

- Check whether Spinal fusion surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Suboxone:

Suboxone (31,249 reports)

Spinal fusion surgery treatments and more:

Spinal fusion surgery (5,167 reports)

How severe was Spinal fusion surgery and when was it recovered:

Spinal fusion surgery in Suboxone

Expand to all the drugs that have ingredients of buprenorphine hydrochloride; naloxone hydrochloride:

Spinal fusion surgery and drugs with ingredients of buprenorphine hydrochloride; naloxone hydrochloride (1 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Suboxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal fusion surgery:

Spinal fusion surgery (493 drugs)

Browse all the conditions that are associated with Spinal fusion surgery:

Spinal fusion surgery (422 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone) and Suboxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.