Supprelin and Device expulsion - a phase IV clinical study of FDA data

Summary:

Device expulsion is reported as a side effect among people who take Supprelin (histrelin acetate), especially for people who are female, 2-9 old, have been taking the drug for 1 - 6 months also take Lupron, and have Precocious puberty.

The phase IV clinical study analyzes which people have Device expulsion when taking Supprelin. It is created by eHealthMe based on reports of 869 people who have side effects when taking Supprelin from the FDA, and is updated regularly.

What is Supprelin?

Supprelin has active ingredients of histrelin acetate. eHealthMe is studying from 874 Supprelin users. Check the latest studies of Supprelin.

What is Device expulsion?

Device expulsion is found to be associated with 267 drugs and 502 conditions by eHealthMe. Check the latest studies of Device expulsion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

869 people reported to have side effects when taking Supprelin.
Among them, 30 people (3.45%) have Device expulsion.

Among these 30 people:

How long have people been on Supprelin when they have Device expulsion? *

What is the gender of people who have Device expulsion when taking Supprelin? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Device expulsion when taking Supprelin? *

What are other drugs people take besides Supprelin? *

What are other side effects people have besides Device expulsion? *

Implant Site Infection: 9 people, 30.00%
Implant Site Erythema (redness at implant site): 5 people, 16.67%
Implant Site Irritation: 5 people, 16.67%
Implant Site Scar: 4 people, 13.33%
Implant Site Abscess: 4 people, 13.33%
Breast Enlargement: 3 people, 10.00%
Procedural Complication: 3 people, 10.00%
Implant Site Discharge: 3 people, 10.00%
Implant Site Induration: 2 people, 6.67%
Upper Limb Fracture: 2 people, 6.67%

What are the existing conditions these people have? *

Precocious Puberty: 17 people, 56.67%
Hypersensitivity: 2 people, 6.67%
Gender Identity Disorder (men or women identify better with the opposite sex): 2 people, 6.67%
Depression: 2 people, 6.67%
Small For Dates Baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age): 1 person, 3.33%
Seasonal Allergy (allergic condition due to certain season): 1 person, 3.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Supprelin and have Device expulsion?

- Check whether Device expulsion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Supprelin:

Supprelin (874 reports)

Device expulsion treatments and more:

Device expulsion (62,538 reports)

Browse all side effects of Supprelin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Device expulsion:

Device expulsion (267 drugs)

Browse all the conditions that are associated with Device expulsion:

Device expulsion (502 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on histrelin acetate (the active ingredients of Supprelin) and Supprelin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.