Symbicort and Proctalgia - a phase IV clinical study of FDA data

Summary:

Proctalgia is reported as a side effect among people who take Symbicort (budesonide; formoterol fumarate dihydrate), especially for people who are female, 60+ old, also take Calcium, and have Crohn's disease.

The phase IV clinical study analyzes which people have Proctalgia when taking Symbicort. It is created by eHealthMe based on reports of 112,650 people who have side effects when taking Symbicort from the FDA, and is updated regularly.

What is Symbicort?

Symbicort has active ingredients of budesonide; formoterol fumarate dihydrate. It is often used in asthma. eHealthMe is studying from 114,792 Symbicort users. Check the latest studies of Symbicort.

What is Proctalgia?

Proctalgia (pain in the rectum) is found to be associated with 770 drugs and 774 conditions by eHealthMe. Check the latest studies of Proctalgia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

112,650 people reported to have side effects when taking Symbicort.
Among them, 49 people (0.04%) have Proctalgia.

Among these 49 people:

What is the gender of people who have Proctalgia when taking Symbicort? *

female: 88.57 %
male: 11.43 %

What is the age of people who have Proctalgia when taking Symbicort? *

What are other drugs people take besides Symbicort? *

Synthroid: 19 people, 38.78%
Calcium: 19 people, 38.78%
Ventolin: 13 people, 26.53%
Inflectra: 13 people, 26.53%
Nicoderm Cq: 12 people, 24.49%
Spiriva: 6 people, 12.24%
Cetirizine Hydrochloride: 6 people, 12.24%
Carvedilol: 6 people, 12.24%
Vancomycin: 6 people, 12.24%
Acetaminophen: 6 people, 12.24%

What are other side effects people have besides Proctalgia? *

Diarrhea: 29 people, 59.18%
Fatigue (feeling of tiredness): 23 people, 46.94%
Nausea (feeling of having an urge to vomit): 18 people, 36.73%
Flatulence (flatus expelled through the anus): 16 people, 32.65%
Constipation: 15 people, 30.61%
Nausea And Vomiting: 14 people, 28.57%
Hepatic Pain (pain in liver): 13 people, 26.53%
High Blood Pressure: 12 people, 24.49%
Pleurisy (inflammation of the pleurae, which causes pain when breathing): 12 people, 24.49%
Choledocholithiasis (stones in the common bile duct): 12 people, 24.49%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 20 people, 40.82%
Pain: 7 people, 14.29%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 8.16%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 8.16%
Staphylococcal Infection (an infection with staphylococcus bacteria): 3 people, 6.12%
Chronic Kidney Disease: 3 people, 6.12%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 6.12%
Pain In Extremity: 3 people, 6.12%
Depression: 3 people, 6.12%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

Do you take Symbicort and have Proctalgia?

- Check whether Proctalgia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Symbicort:

Symbicort (114,792 reports)

Proctalgia treatments and more:

Proctalgia (9,250 reports)

How severe was Proctalgia and when was it recovered:

Proctalgia in Symbicort

Expand to all the drugs that have ingredients of budesonide; formoterol fumarate dihydrate:

Proctalgia and drugs with ingredients of budesonide; formoterol fumarate dihydrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Symbicort:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Proctalgia:

Proctalgia (770 drugs)

Browse all the conditions that are associated with Proctalgia:

Proctalgia (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on budesonide; formoterol fumarate dihydrate (the active ingredients of Symbicort) and Symbicort (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.