Symproic and Intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Intestinal obstruction is reported as a side effect among people who take Symproic (naldemedine tosylate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Oxycontin, and have Constipation.

The phase IV clinical study analyzes which people have Intestinal obstruction when taking Symproic. It is created by eHealthMe based on reports of 1,485 people who have side effects when taking Symproic from the FDA, and is updated regularly.

What is Symproic?

Symproic has active ingredients of naldemedine tosylate. eHealthMe is studying from 1,487 Symproic users. Check the latest studies of Symproic.

What is Intestinal obstruction?

Intestinal obstruction is found to be associated with 1,887 drugs and 2,613 conditions by eHealthMe. Check the latest studies of Intestinal obstruction.

On Apr, 27, 2026

1,485 people reported to have side effects when taking Symproic.
Among them, 21 people (1.41%) have Intestinal obstruction.

Could Symproic cause Intestinal obstruction?

Among these 21 people:

How long have people been on Symproic when they have Intestinal obstruction? *

What is the gender of people who have Intestinal obstruction when taking Symproic? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Intestinal obstruction when taking Symproic? *

What are other drugs people take besides Symproic? *

What are other side effects people have besides Intestinal obstruction? *

Abdominal Pain: 4 people, 19.05%
Constipation: 4 people, 19.05%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 4 people, 19.05%
Fever: 2 people, 9.52%
Dyspnea (difficult or laboured breathing): 2 people, 9.52%
Nausea And Vomiting: 2 people, 9.52%
Malignant Neoplasm Progression (cancer tumour came back): 2 people, 9.52%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 9.52%
Haematemesis (vomiting of blood): 2 people, 9.52%
Bladder Perforation (bladder trauma): 1 person, 4.76%

What are the existing conditions these people have? *

Constipation: 13 people, 61.90%
Cancer Pain: 8 people, 38.10%
Pain: 5 people, 23.81%
Tumor Pain: 4 people, 19.05%
Nausea (feeling of having an urge to vomit): 4 people, 19.05%
Diarrhea: 4 people, 19.05%
Dry Skin: 4 people, 19.05%
General Anaesthesia: 4 people, 19.05%
High Blood Cholesterol: 4 people, 19.05%
Infusion Site Extravasation (flow of (blood or lymph) from infusion site): 4 people, 19.05%

* Approximation only. Some reports may have incomplete information.

Do you take Symproic and have Intestinal obstruction?

- Check whether Intestinal obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Symproic:

Symproic (1,487 reports)

Browse all side effects of Symproic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal obstruction:

Intestinal obstruction (1,887 drugs)

Browse all the conditions that are associated with Intestinal obstruction:

Intestinal obstruction (2,613 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naldemedine tosylate (the active ingredients of Symproic) and Symproic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.