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Synthroid and Apical granuloma - a phase IV clinical study of FDA data

Summary:

Apical granuloma is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 40-49 old, also take Aredia, and have Breast cancer.

The phase IV clinical study analyzes which people have Apical granuloma when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.

What is Apical granuloma?

Apical granuloma (tumour of the apex of a nonvital tooth) is found to be associated with 44 drugs and 52 conditions by eHealthMe. Check the latest studies of Apical granuloma.

On Aug, 07, 2026

237,758 people reported to have side effects when taking Synthroid.
Among them, 11 people (0.0%) have Apical granuloma.

Could Synthroid cause Apical granuloma?

Among these 11 people:

What is the gender of people who have Apical granuloma when taking Synthroid? *

  • female: 72.73 %
  • male: 27.27 %

What is the age of people who have Apical granuloma when taking Synthroid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 9.09 %
  • 40-49: 63.64 %
  • 50-59: 0.0 %
  • 60+: 27.27 %

What are other drugs people take besides Synthroid? *

  1. Zometa: 11 people, 100.00%
  2. Aredia: 11 people, 100.00%
  3. Rocephin: 8 people, 72.73%
  4. Aromasin: 8 people, 72.73%
  5. Ativan: 8 people, 72.73%
  6. Cytoxan: 8 people, 72.73%
  7. Dolobid: 8 people, 72.73%
  8. Femara: 8 people, 72.73%
  9. Zoloft: 8 people, 72.73%
  10. Nolvadex: 8 people, 72.73%

What are other side effects people have besides Apical granuloma? *

  1. Pneumonia: 11 people, 100.00%
  2. Adenoma Benign (non-cancerous tumour -secreting): 11 people, 100.00%
  3. Gums - Swollen: 11 people, 100.00%
  4. Toothaches (tooth pain): 11 people, 100.00%
  5. Bone Disorder: 11 people, 100.00%
  6. Tooth Disorder (tooth disease): 11 people, 100.00%
  7. Fever: 11 people, 100.00%
  8. Infection: 11 people, 100.00%
  9. Oedema Peripheral (superficial swelling): 9 people, 81.82%
  10. Inflammation: 8 people, 72.73%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 8 people, 72.73%
  2. Metastases To Bone (cancer spreads to bone): 8 people, 72.73%
  3. Chronic Thyroiditis (long lasting inflammation of thyroid gland): 8 people, 72.73%
  4. Breast Cancer: 8 people, 72.73%
  5. Multiple Myeloma (cancer of the plasma cells): 3 people, 27.27%
  6. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Apical granuloma?

- Check whether Apical granuloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Apical granuloma treatments and more:

How severe was Apical granuloma and when was it recovered:

Expand to all the drugs that have ingredients of levothyroxine sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apical granuloma:

Browse all the conditions that are associated with Apical granuloma:

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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