Synthroid and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Coumadin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Coma when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,182 Synthroid users. Check the latest studies of Synthroid.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,891 drugs and 3,169 conditions by eHealthMe. Check the latest studies of Coma.

On Sep, 26, 2025

237,758 people reported to have side effects when taking Synthroid.
Among them, 530 people (0.22%) have Coma.

Among these 530 people:

How long have people been on Synthroid when they have Coma? *

What is the gender of people who have Coma when taking Synthroid? *

female: 80.19 %
male: 19.81 %

What is the age of people who have Coma when taking Synthroid? *

What are other drugs people take besides Synthroid? *

What are other side effects people have besides Coma? *

Fatigue (feeling of tiredness): 105 people, 19.81%
Weakness: 104 people, 19.62%
Fall: 102 people, 19.25%
Hypotension (abnormally low blood pressure): 90 people, 16.98%
Nausea (feeling of having an urge to vomit): 86 people, 16.23%
Dyspnea (difficult or laboured breathing): 83 people, 15.66%
Nausea And Vomiting: 80 people, 15.09%
Pain: 79 people, 14.91%
Fever: 76 people, 14.34%
Headache (pain in head): 72 people, 13.58%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 59 people, 11.13%
Depression: 31 people, 5.85%
High Blood Pressure: 28 people, 5.28%
Pain: 26 people, 4.91%
Stress And Anxiety: 24 people, 4.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 18 people, 3.40%
Diabetes: 17 people, 3.21%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 15 people, 2.83%
Osteoporosis (bones weak and more likely to break): 15 people, 2.83%
Bipolar Disorder (mood disorder): 14 people, 2.64%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Coma?

- Check whether Coma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Synthroid (249,182 reports)

Coma treatments and more:

Coma (57,420 reports)

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Coma:

Browse all the drugs that are associated with Coma:

Coma (2,891 drugs)

Common conditions associated with Coma:

Pain exacerbated: 2,578 reports
Hypnosis and pain: 2,471 reports
Depression aggravated: 1,998 reports
Antidepressant therapy: 1,968 reports
Hypertension: 1,963 reports
Blood pressure - high: 1,924 reports
Multiple sclerosis aggravated: 1,512 reports
Acupuncture and pain: 1,424 reports
Rheumatoid arthritis aggravated: 1,182 reports
Diabetes mellitus: 1,167 reports

Browse all the conditions that are associated with Coma:

Coma (3,169 conditions)

Drugs similar to Synthroid and Coma :

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.