Synthroid and Earache - a phase IV clinical study of FDA data


Earache is found among people who take Synthroid, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Synthroid and have Earache. It is created by eHealthMe based on reports of 203,083 people who have side effects when taking Synthroid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jul, 10, 2022

203,083 people reported to have side effects when taking Synthroid.
Among them, 31 people (0.02%) have Earache.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 213,711 Synthroid users for its effectiveness, alternative drugs and more.

What is Earache?

Earache (ear pain) is found to be associated with 629 drugs by eHealthMe.

Number of Synthroid and Earache reports submitted per year:

Could Synthroid cause Earache?

Gender of people who have Earache when taking Synthroid *:

  • female: 74.19 %
  • male: 25.81 %

Age of people who have Earache when taking Synthroid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 11.11 %
  • 30-39: 3.7 %
  • 40-49: 7.41 %
  • 50-59: 22.22 %
  • 60+: 55.56 %

Common drugs people take besides Synthroid *:

  1. Zoloft: 5 people, 16.13%
  2. Prozac: 4 people, 12.90%
  3. Calcium: 4 people, 12.90%
  4. Cataflam: 3 people, 9.68%
  5. Depo-Estradiol: 3 people, 9.68%
  6. Prinivil: 3 people, 9.68%
  7. Premarin: 3 people, 9.68%
  8. Ultram: 3 people, 9.68%
  9. Amaryl: 3 people, 9.68%
  10. Rezulin: 3 people, 9.68%

Common side effects people have besides Earache *:

  1. Weakness: 8 people, 25.81%
  2. Chest Pain: 7 people, 22.58%
  3. Cough: 7 people, 22.58%
  4. High Blood Cholesterol: 6 people, 19.35%
  5. Confusion: 6 people, 19.35%
  6. Fatigue (feeling of tiredness): 6 people, 19.35%
  7. Pain In Limb: 5 people, 16.13%
  8. Joint Pain: 5 people, 16.13%
  9. Muscle Aches (muscle pain): 4 people, 12.90%
  10. Sweating Increased (excess sweating): 4 people, 12.90%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Earache?

Check whether Earache is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Synthroid:

Earache treatments and more:

COVID vaccines that are related to Earache:

How severe was Earache and when was it recovered:

Expand to all the drugs that have ingredients of levothyroxine sodium:

All the drugs that are associated with Earache:

All the conditions that are associated with Earache:

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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