Synthroid and Headache - a phase IV clinical study of FDA data
Summary:
Headache is found among people who take Synthroid, especially for people who are female, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Synthroid and have Headache. It is created by eHealthMe based on reports of 215,853 people who have side effects when taking Synthroid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
215,853 people reported to have side effects when taking Synthroid.
Among them, 14,633 people (6.78%) have Headache.
What is Synthroid?
Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 226,976 Synthroid users for its effectiveness, alternative drugs and more.
What is Headache?
Headache (pain in head) is found to be associated with 5,224 drugs and 5,614 conditions by eHealthMe.
Number of Synthroid and Headache reports submitted per year:

Time on Synthroid when people have Headache *:
Gender of people who have Headache when taking Synthroid*:
Age of people who have Headache when taking Synthroid *:
Common drugs people take besides Synthroid *:
Common side effects people have besides Headache *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Synthroid and have Headache?
Check whether Headache is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Headache and when was it recovered:
Expand to all the drugs that have ingredients of levothyroxine sodium:
- Headache and drugs with ingredients of levothyroxine sodium (31,829 reports)
Alternative drugs to, pros and cons of Synthroid:
- Synthroid (226,976 reports)
Common Synthroid side effects:
- Fatigue (feeling of tiredness): 20,619 reports
- Drug ineffective: 16,072 reports
- Headache (pain in head): 14,633 reports
- Pain: 13,929 reports
- Diarrhea: 13,797 reports
- Weakness: 13,556 reports
Browse all side effects of Synthroid:
a b c d e f g h i j k l m n o p q r s t u v w x y zHeadache treatments and more:
- Headache (652,090 reports)
COVID vaccines that are related to Headache:
- Headache in Moderna COVID Vaccine
- Headache in Pfizer BioNTech Covid Vaccine
- Headache in Johnson and Johnson Covid Vaccine
Common drugs associated with Headache:
- Prednisone: 28,266 reports
- Humira: 26,867 reports
- Methotrexate: 25,739 reports
- Enbrel: 25,302 reports
- Aspirin: 21,238 reports
- Otezla: 16,774 reports
- Omeprazole: 15,229 reports
- Tylenol: 15,040 reports
- Vitamin d: 14,927 reports
- Synthroid: 14,633 reports
All the drugs that are associated with Headache:
- Headache (5,224 drugs)
Common conditions associated with Headache:
- Multiple sclerosis: 41,461 reports
- Rheumatoid arthritis: 40,932 reports
- High blood pressure: 23,165 reports
- Primary pulmonary hypertension: 21,717 reports
- Psoriasis: 19,045 reports
- Depression: 18,850 reports
All the conditions that are associated with Headache:
- Headache (5,614 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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