Synthroid and Hyperbilirubinaemia - a phase IV clinical study of FDA data

Summary:

Hyperbilirubinaemia is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Hyperbilirubinaemia when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,205 Synthroid users. Check the latest studies of Synthroid.

What is Hyperbilirubinaemia?

Hyperbilirubinaemia (excess of bilirubin in the blood) is found to be associated with 901 drugs and 1,074 conditions by eHealthMe. Check the latest studies of Hyperbilirubinaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

237,758 people reported to have side effects when taking Synthroid.
Among them, 80 people (0.03%) have Hyperbilirubinaemia.

Could Synthroid cause Hyperbilirubinaemia?

Among these 80 people:

How long have people been on Synthroid when they have Hyperbilirubinaemia? *

What is the gender of people who have Hyperbilirubinaemia when taking Synthroid? *

female: 66.23 %
male: 33.77 %

What is the age of people who have Hyperbilirubinaemia when taking Synthroid? *

What are other drugs people take besides Synthroid? *

What are other side effects people have besides Hyperbilirubinaemia? *

Thrombocytopenia (decrease of platelets in blood): 19 people, 23.75%
Anaemia (lack of blood): 18 people, 22.50%
Nausea (feeling of having an urge to vomit): 17 people, 21.25%
Abdominal Pain: 17 people, 21.25%
Diarrhea: 16 people, 20.00%
Fatigue (feeling of tiredness): 15 people, 18.75%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 15 people, 18.75%
Hypokalemia (low potassium): 12 people, 15.00%
Fever: 11 people, 13.75%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 13.75%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 7.50%
Cardiac Disorder: 5 people, 6.25%
Depression: 5 people, 6.25%
Colon Cancer: 5 people, 6.25%
Nausea (feeling of having an urge to vomit): 4 people, 5.00%
Tumor Lysis Syndrome: 3 people, 3.75%
Agitation (state of anxiety or nervous excitement): 3 people, 3.75%
Pain: 3 people, 3.75%
Nausea And Vomiting: 3 people, 3.75%
Neoplasm Malignant (cancer tumour): 2 people, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Hyperbilirubinaemia?

- Check whether Hyperbilirubinaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Synthroid (249,205 reports)

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperbilirubinaemia:

Hyperbilirubinaemia (901 drugs)

Browse all the conditions that are associated with Hyperbilirubinaemia:

Hyperbilirubinaemia (1,074 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.