Synthroid and Mitral valve replacement - a phase IV clinical study of FDA data

Summary:

Mitral valve replacement is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Lasix, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Mitral valve replacement when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.

What is Mitral valve replacement?

Mitral valve replacement is found to be associated with 93 drugs and 161 conditions by eHealthMe. Check the latest studies of Mitral valve replacement.

On Aug, 12, 2026

237,758 people reported to have side effects when taking Synthroid.
Among them, 12 people (0.01%) have Mitral valve replacement.

Could Synthroid cause Mitral valve replacement?

Among these 12 people:

How long have people been on Synthroid when they have Mitral valve replacement? *

What is the gender of people who have Mitral valve replacement when taking Synthroid? *

female: 100 %
male: 0.0 %

What is the age of people who have Mitral valve replacement when taking Synthroid? *

What are other drugs people take besides Synthroid? *

What are other side effects people have besides Mitral valve replacement? *

Joint Pain: 4 people, 33.33%
Fever: 3 people, 25.00%
Weakness: 3 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 25.00%
Chest Pain: 3 people, 25.00%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 3 people, 25.00%
Pleural Effusion (water on the lungs): 2 people, 16.67%
Gout (uric acid crystals building up in the body): 2 people, 16.67%
Fatigue (feeling of tiredness): 2 people, 16.67%
Depression: 2 people, 16.67%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 2 people, 16.67%
Confusional State: 2 people, 16.67%
Cardiac Failure: 2 people, 16.67%
Blood Pressure Abnormal: 2 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
Pain: 1 person, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%
Iron Overload: 1 person, 8.33%
Drowsiness: 1 person, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Mitral valve replacement?

- Check whether Mitral valve replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Synthroid (249,202 reports)

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mitral valve replacement:

Mitral valve replacement (93 drugs)

Browse all the conditions that are associated with Mitral valve replacement:

Mitral valve replacement (161 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.