Synthroid and Negative thoughts - a phase IV clinical study of FDA data

Summary:

Negative thoughts is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 30-39 old, also take Ambien, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Negative thoughts when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,168 Synthroid users. Check the latest studies of Synthroid.

What is Negative thoughts?

Negative thoughts is found to be associated with 289 drugs and 399 conditions by eHealthMe. Check the latest studies of Negative thoughts.

On Oct, 27, 2025

237,758 people reported to have side effects when taking Synthroid.
Among them, 39 people (0.02%) have Negative thoughts.

Could Synthroid cause Negative thoughts?

Among these 39 people:

What is the gender of people who have Negative thoughts when taking Synthroid? *

female: 79.49 %
male: 20.51 %

What is the age of people who have Negative thoughts when taking Synthroid? *

What are other drugs people take besides Synthroid? *

What are other side effects people have besides Negative thoughts? *

Insomnia (sleeplessness): 20 people, 51.28%
Suicidal Ideation: 20 people, 51.28%
Nausea (feeling of having an urge to vomit): 18 people, 46.15%
Headache (pain in head): 18 people, 46.15%
Feeling Abnormal: 16 people, 41.03%
Fatigue (feeling of tiredness): 16 people, 41.03%
Nightmares (unpleasant dreams): 15 people, 38.46%
Crying: 13 people, 33.33%
Depressed Mood: 13 people, 33.33%
Dyspnea (difficult or laboured breathing): 13 people, 33.33%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 12 people, 30.77%
Post-Traumatic Stress Disorder: 10 people, 25.64%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.26%
Polycythemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 7.69%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 7.69%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.69%
Depression: 3 people, 7.69%
Pain: 3 people, 7.69%
Joint Pain: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Negative thoughts?

- Check whether Negative thoughts is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Synthroid (249,168 reports)

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Negative thoughts:

Negative thoughts (289 drugs)

Browse all the conditions that are associated with Negative thoughts:

Negative thoughts (399 conditions)

Drugs similar to Synthroid and Negative thoughts :

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.