Synthroid and Rebound effect - a phase IV clinical study of FDA data

Summary:

Rebound effect is reported as a side effect among people who take Synthroid (levothyroxine sodium), especially for people who are female, 40-49 old, also take Paxlovid, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Rebound effect when taking Synthroid. It is created by eHealthMe based on reports of 237,758 people who have side effects when taking Synthroid from the FDA, and is updated regularly.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,196 Synthroid users. Check the latest studies of Synthroid.

What is Rebound effect?

Rebound effect (take-back effect) is found to be associated with 371 drugs and 565 conditions by eHealthMe. Check the latest studies of Rebound effect.

On May, 24, 2026

237,758 people reported to have side effects when taking Synthroid.
Among them, 31 people (0.01%) have Rebound effect.

Among these 31 people:

* Approximation only. Some reports may have incomplete information.

Do you take Synthroid and have Rebound effect?

- Check whether Rebound effect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Synthroid:

Synthroid (249,196 reports)

Rebound effect treatments and more:

Rebound effect (8,859 reports)

How severe was Rebound effect and when was it recovered:

Rebound effect in Synthroid

Expand to all the drugs that have ingredients of levothyroxine sodium:

Rebound effect and drugs with ingredients of levothyroxine sodium (148 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Synthroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rebound effect:

Rebound effect (371 drugs)

Browse all the conditions that are associated with Rebound effect:

Rebound effect (565 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium (the active ingredients of Synthroid) and Synthroid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.