Tacrolimus and Extremity necrosis - a phase IV clinical study of FDA data

Summary:

Extremity necrosis is reported as a side effect among people who take Tacrolimus (tacrolimus), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Simulect, and have Sedation.

The phase IV clinical study analyzes which people have Extremity necrosis when taking Tacrolimus. It is created by eHealthMe based on reports of 115,828 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

What is Extremity necrosis?

Extremity necrosis (death of body tissue of arms and legs) is found to be associated with 300 drugs and 409 conditions by eHealthMe. Check the latest studies of Extremity necrosis.

On Jul, 14, 2026

115,828 people reported to have side effects when taking Tacrolimus.
Among them, 37 people (0.03%) have Extremity necrosis.

Could Tacrolimus cause Extremity necrosis?

Among these 37 people:

How long have people been on Tacrolimus when they have Extremity necrosis? *

What is the gender of people who have Extremity necrosis when taking Tacrolimus? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Extremity necrosis when taking Tacrolimus? *

What are other drugs people take besides Tacrolimus? *

Simulect: 25 people, 67.57%
Midazolam: 22 people, 59.46%
Clopidogrel: 18 people, 48.65%
Ciclosporin: 16 people, 43.24%
Acetylsalicylic Acid: 14 people, 37.84%
Piperacillin And Tazobactam: 12 people, 32.43%
Sulfamethoxazole And Trimethoprim: 6 people, 16.22%
Envarsus Xr: 6 people, 16.22%
Mycophenolate Mofetil: 4 people, 10.81%
Prilosec: 3 people, 8.11%

What are other side effects people have besides Extremity necrosis? *

Cardiac Failure: 25 people, 67.57%
Pneumonia: 25 people, 67.57%
Cardiac Arrest: 24 people, 64.86%
Transplant Rejection (a transplant material is not worked): 24 people, 64.86%
Acid Base Balance Abnormal: 23 people, 62.16%
Hypotonia (low muscle tone): 23 people, 62.16%
Diabetic Macroangiopathy (fat and blood clots build up in the large blood vessels due to diabetes): 23 people, 62.16%
Cardiogenic Shock (inadequate circulation of blood): 23 people, 62.16%
Immunosuppressant Drug Level Increased: 23 people, 62.16%
Brain Natriuretic Peptide Increased: 23 people, 62.16%

What are the existing conditions these people have? *

Sedation: 23 people, 62.16%
C-Reactive Protein Increased: 14 people, 37.84%
Cardiac Disorder: 12 people, 32.43%
Immune Tolerance Induction: 12 people, 32.43%
Urinary Tract Infection: 7 people, 18.92%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 7 people, 18.92%
Diabetes: 6 people, 16.22%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 8.11%
Transplant Rejection (a transplant material is not worked): 3 people, 8.11%
Gout (uric acid crystals building up in the body): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

Do you take Tacrolimus and have Extremity necrosis?

- Check whether Extremity necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tacrolimus:

Tacrolimus (116,160 reports)

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extremity necrosis:

Extremity necrosis (300 drugs)

Browse all the conditions that are associated with Extremity necrosis:

Extremity necrosis (409 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.