Tacrolimus and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Tacrolimus (tacrolimus), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Immunodeficiency disorders.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Tacrolimus. It is created by eHealthMe based on reports of 115,828 people who have side effects when taking Tacrolimus from the FDA, and is updated regularly.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 778 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

115,828 people reported to have side effects when taking Tacrolimus.
Among them, 60 people (0.05%) have Hyperkeratosis.

Among these 60 people:

How long have people been on Tacrolimus when they have Hyperkeratosis? *

What is the gender of people who have Hyperkeratosis when taking Tacrolimus? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hyperkeratosis when taking Tacrolimus? *

What are other drugs people take besides Tacrolimus? *

Cellcept: 16 people, 26.67%
Prednisone: 16 people, 26.67%
Mycophenolate Mofetil: 14 people, 23.33%
Prograf: 11 people, 18.33%
Prilosec: 10 people, 16.67%
Magnevist: 10 people, 16.67%
Colace: 10 people, 16.67%
Lasix: 10 people, 16.67%
Renagel: 10 people, 16.67%
Miralax: 9 people, 15.00%

What are other side effects people have besides Hyperkeratosis? *

Rashes (redness): 31 people, 51.67%
Hair Loss: 18 people, 30.00%
Itching: 13 people, 21.67%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 11 people, 18.33%
Gait Disturbance: 11 people, 18.33%
Weakness: 10 people, 16.67%
Skin Induration (an abnormally hard spot or area on the skin): 10 people, 16.67%
Acanthosis (thickening of the skin): 10 people, 16.67%
Dry Skin: 10 people, 16.67%
Fatigue (feeling of tiredness): 10 people, 16.67%

What are the existing conditions these people have? *

Immunodeficiency Disorders: 11 people, 18.33%
Polymyalgia Rheumatica (pain in many muscles): 9 people, 15.00%
Anaemia (lack of blood): 9 people, 15.00%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 9 people, 15.00%
Depression: 9 people, 15.00%
Type 2 Diabetes: 6 people, 10.00%
Nuclear Magnetic Resonance Imaging Brain: 5 people, 8.33%
Lipids Increased (excess lipid in body): 3 people, 5.00%
Human Herpesvirus 6 Infection: 3 people, 5.00%
High Blood Pressure: 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tacrolimus and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tacrolimus:

Tacrolimus (116,160 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Tacrolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (778 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Tacrolimus) and Tacrolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.