Testosterone and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Testosterone (testosterone), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Aspirin, and have Depression.

The phase IV clinical study analyzes which people have Joint stiffness when taking Testosterone. It is created by eHealthMe based on reports of 5,651 people who have side effects when taking Testosterone from the FDA, and is updated regularly.

What is Testosterone?

Testosterone has active ingredients of testosterone. It is often used in testosterone. eHealthMe is studying from 6,457 Testosterone users. Check the latest studies of Testosterone.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,301 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

5,651 people reported to have side effects when taking Testosterone.
Among them, 17 people (0.3%) have Joint stiffness.

Could Testosterone cause Joint stiffness?

Among these 17 people:

How long have people been on Testosterone when they have Joint stiffness? *

What is the gender of people who have Joint stiffness when taking Testosterone? *

female: 11.76 %
male: 88.24 %

What is the age of people who have Joint stiffness when taking Testosterone? *

What are other drugs people take besides Testosterone? *

What are other side effects people have besides Joint stiffness? *

Joint Pain: 9 people, 52.94%
Pain: 8 people, 47.06%
Fatigue (feeling of tiredness): 7 people, 41.18%
Gait Disturbance: 7 people, 41.18%
Stress And Anxiety: 7 people, 41.18%
Muscle Aches (muscle pain): 6 people, 35.29%
Weakness: 5 people, 29.41%
Emotional Distress: 5 people, 29.41%
Mobility Decreased (ability to move is reduced): 5 people, 29.41%
Rashes (redness): 4 people, 23.53%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 17.65%
Anaemia (lack of blood): 3 people, 17.65%
Polymyalgia Rheumatica (pain in many muscles): 3 people, 17.65%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 3 people, 17.65%
Depression: 3 people, 17.65%
Upper Respiratory Tract Infection: 2 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%
High Blood Cholesterol: 2 people, 11.76%
Hiv Infection: 2 people, 11.76%
Nasal Polyps (masses that develop in the lining of the nose): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Testosterone and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Testosterone:

Testosterone (6,457 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Testosterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,301 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on testosterone (the active ingredients of Testosterone) and Testosterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.