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Timoptic-xe and Insomnia exacerbated - a phase IV clinical study of FDA data

Summary:

Insomnia exacerbated is reported as a side effect among people who take Timoptic-xe (timolol maleate), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Hyzaar, and have Atrial tachycardia.

The phase IV clinical study analyzes which people have Insomnia exacerbated when taking Timoptic-xe. It is created by eHealthMe based on reports of 480 people who have side effects when taking Timoptic-xe from the FDA, and is updated regularly.

What is Timoptic-xe?

Timoptic-xe has active ingredients of timolol maleate. It is often used in glaucoma. eHealthMe is studying from 488 Timoptic-xe users. Check the latest studies of Timoptic-xe.

What is Insomnia exacerbated?

Insomnia exacerbated (severe sleeplessness) is found to be associated with 2,649 drugs and 974 conditions by eHealthMe. Check the latest studies of Insomnia exacerbated.

On Jul, 12, 2026

480 people reported to have side effects when taking Timoptic-xe.
Among them, 15 people (3.13%) have Insomnia exacerbated.

Could Timoptic-xe cause Insomnia exacerbated?

Among these 15 people:

How long have people been on Timoptic-xe when they have Insomnia exacerbated? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Insomnia exacerbated when taking Timoptic-xe? *

  • female: 53.33 %
  • male: 46.67 %

What is the age of people who have Insomnia exacerbated when taking Timoptic-xe? *

  • 0-1: 0.0 %
  • 2-9: 8.33 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 16.67 %
  • 40-49: 0.0 %
  • 50-59: 16.67 %
  • 60+: 58.33 %

What are other drugs people take besides Timoptic-xe? *

  1. Hyzaar: 3 people, 20.00%
  2. Pravastatin Sodium: 2 people, 13.33%
  3. Xalatan: 2 people, 13.33%
  4. Vioxx: 2 people, 13.33%
  5. Arimidex: 2 people, 13.33%
  6. Lorazepam: 2 people, 13.33%
  7. Effexor: 2 people, 13.33%
  8. Neurontin: 2 people, 13.33%
  9. Norvasc: 2 people, 13.33%
  10. Hydrochlorothiazide: 1 person, 6.67%

What are other side effects people have besides Insomnia exacerbated? *

  1. Nausea (feeling of having an urge to vomit): 6 people, 40.00%
  2. Cough: 5 people, 33.33%
  3. Fatigue (feeling of tiredness): 5 people, 33.33%
  4. Weakness: 4 people, 26.67%
  5. Weight Decreased: 3 people, 20.00%
  6. Peripheral Coldness: 3 people, 20.00%
  7. Memory Loss: 3 people, 20.00%
  8. Headache (pain in head): 3 people, 20.00%
  9. Dyspnea (difficult or laboured breathing): 3 people, 20.00%
  10. Tinnitus (a ringing in the ears): 3 people, 20.00%

What are the existing conditions these people have? *

  1. Depression: 1 person, 6.67%
  2. Atrial Tachycardia (rhythm disturbance that arises in the atria): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Timoptic-xe and have Insomnia exacerbated?

- Check whether Insomnia exacerbated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Timoptic-xe:

Insomnia exacerbated treatments and more:

How severe was Insomnia exacerbated and when was it recovered:

Expand to all the drugs that have ingredients of timolol maleate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Timoptic-xe:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia exacerbated:

Browse all the conditions that are associated with Insomnia exacerbated:

How the study uses the data?

The study uses data from the FDA. It is based on timolol maleate (the active ingredients of Timoptic-xe) and Timoptic-xe (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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